A DTI-derived measure of cortico-cortical connectivity

IEEE Transactions on Medical Imaging
Andrew Zalesky, Alex Fornito

Abstract

We arm researchers with a simple method to chart a macroscopic cortico-cortical connectivity network in living human subjects. The researcher provides a diffusion-magnetic resonance imaging (MRI) data set and N cortical regions of interest. In return, we provide an N xN structural adjacency matrix (SAM) quantifying the relative connectivity between all cortical region pairs. We also return a connectivity map for each pair to enable visualization of interconnecting fiber bundles. The measure of connectivity we devise is: 1) free of length bias, 2) proportional to fiber bundle cross-sectional area, and 3) invariant to an exchange of seed and target. We construct a 3-D lattice scaffolding (graph) for white-matter by drawing a link between each pair of voxels in a 26-voxel neighborhood for which their two respective principal eigenvectors form a sufficiently small angle. The connectivity between a cortical region pair is then measured as the maximum number of link-disjoint paths that can be established between them in the white-matter graph. We devise an efficient Edmonds-Karp-like algorithm to compute a conservative bound on the maximum number of link-disjoint paths. Using both simulated and authentic diffusion-tensor imaging data...Continue Reading

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Citations

Jul 27, 2012·Neuroscience Bulletin·Nianming ZuoTianzi Jiang
Feb 28, 2013·Brain Connectivity·Petra RitterViktor K Jirsa
May 25, 2013·Brain Connectivity·Madelaine DaianuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
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Apr 9, 2013·Brain Structure & Function·Andrew ZaleskyGary F Egan
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Jan 24, 2016·Brain Imaging and Behavior·Aldo Córdova-PalomeraLourdes Fañanás
Oct 16, 2015·Human Brain Mapping·Anil M TuladharFrank-Erik de Leeuw
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Jul 6, 2010·NeuroImage·Andrew ZaleskyEdward T Bullmore
Apr 15, 2010·Brain Research Reviews·Jerome J MallerPaul B Fitzgerald
Sep 4, 2015·NeuroImage·Andreas Horn, Felix Blankenburg
Nov 19, 2015·Frontiers in Neurology·Maria Inez FalconAna Solodkin
Feb 19, 2016·Neurology·Anil M TuladharFrank-Erik de Leeuw
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Nov 3, 2010·Biological Psychiatry·Andrew ZaleskyChristos Pantelis
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Apr 15, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alex Fornito, Edward T Bullmore
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Feb 24, 2015·Nature Reviews. Neuroscience·Alex FornitoMichael Breakspear
Sep 23, 2014·Current Opinion in Neurobiology·Alex Fornito, Edward T Bullmore
Jul 2, 2016·NeuroImage·Andrew ZaleskyMichael Breakspear
Sep 27, 2016·NeuroImage·James A RobertsMichael Breakspear

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