A dual boundary classifier for predicting acute hypotensive episodes in critical care

PloS One
Sakyajit BhattacharyaChandan K Reddy

Abstract

An Acute Hypotensive Episode (AHE) is the sudden onset of a sustained period of low blood pressure and is one among the most critical conditions in Intensive Care Units (ICU). Without timely medical care, it can lead to an irreversible organ damage and death. By identifying patients at risk for AHE early, adequate medical intervention can save lives and improve patient outcomes. In this paper, we design a novel dual-boundary classification based approach for identifying patients at risk for AHE. Our algorithm uses only simple summary statistics of past Blood Pressure measurements and can be used in an online environment facilitating real-time updates and prediction. We perform extensive experiments with more than 4,500 patient records and demonstrate that our method outperforms the previous best approaches of AHE prediction. Our method can identify AHE patients two hours in advance of the onset, giving sufficient time for appropriate clinical intervention with nearly 80% sensitivity and at 95% specificity, thus having very few false positives.

References

Jan 1, 1991·Intensive Care Medicine·J H SchaeferA Distler
Nov 1, 1996·Critical Care Medicine·P A HeidenreichN H Cohen
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Jun 3, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Anthony StellIan Piper
Jan 5, 2011·Critical Care Medicine·Jukka Takala
Jan 1, 2008·Computers in Cardiology·Lh LehmanRg Mark
Sep 9, 2011·Computers in Biology and Medicine·Teresa RochaJorge Henriques
Apr 6, 2012·Acta Neurochirurgica. Supplement·Rob DonaldA Stell
Mar 6, 2013·The Journal of Clinical Hypertension·Cyndya ShibaoItalo Biaggioni
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Jun 27, 2014·IEEE Journal of Biomedical and Health Informatics·M S NeofytouConstantinos Pattichis

❮ Previous
Next ❯

Citations

Jan 28, 2021·Military Medicine·Navid RashediNorman A Paradis
Mar 17, 2020·Computers in Biology and Medicine·Mina Chookhachizadeh MoghadamZeev N Kain

❮ Previous
Next ❯

Software Mentioned

Random
e1071
Ada
Physionet
SVM
R
Class

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Lijuan LaiDongsheng Xiong
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Dazhi JiangChenfeng Peng
Healthcare Informatics : the Business Magazine for Information and Communication Systems
C Safran
© 2022 Meta ULC. All rights reserved