A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate

Chemical Communications : Chem Comm
Yu FangHuimin Ma

Abstract

A new dual-function fluorescent probe is developed for detecting nitroreductase (NTR) and adenosine triphosphate (ATP) with different responses. Imaging application of the probe reveals that intracellular NTR and ATP display an adverse changing trend during a hypoxic process and ATP can serve as a new sign for cell hypoxia.

References

Jan 1, 1980·Annual Review of Biochemistry·J R Knowles
Nov 9, 1994·Molecular and Cellular Biochemistry·T W Traut
Jan 19, 2000·Molecular Medicine Today·M StubbsC L Bashford
Jun 28, 2003·Stroke; a Journal of Cerebral Circulation·Konstantin PrassAndreas Meisel
Aug 21, 2003·Cancer Treatment Reviews·Aoife M ShannonDeirdre Toomey
Aug 17, 2005·Pharmacology & Therapeutics·Heike Franke, Peter Illes
May 27, 2006·Science·Ken Garber
Feb 15, 2008·Nature Reviews. Cancer·Robert G Bristow, Richard P Hill
May 25, 2011·Nature Reviews. Cancer·William R Wilson, Michael P Hay
Oct 29, 2014·Chemical Communications : Chem Comm·Jia-Liang TangChun-Xiang Zou
Feb 14, 2015·Chemical Communications : Chem Comm·Peisheng ZhangShuizhu Wu
Apr 30, 2015·Journal of the American Chemical Society·Yuhao LiFuyou Li
Aug 30, 2016·Journal of the American Chemical Society·Arnaud ChevalierSidney M Hecht
Dec 6, 2016·Chemical Communications : Chem Comm·Debabrata MaityCarsten Schmuck
Mar 8, 2017·Organic & Biomolecular Chemistry·Sylvain Debieu, Anthony Romieu
Apr 4, 2017·Chemical Communications : Chem Comm·Jiang-Hua ZhuJong Seung Kim
Sep 28, 2017·Chemical Communications : Chem Comm·Shengnan XuHai-Yu Hu

❮ Previous
Next ❯

Citations

Jun 18, 2019·Chemical Society Reviews·Yongkang YueCaixia Yin
Aug 1, 2019·Chemical Communications : Chem Comm·Zhichao LiuYang Tian
Jan 31, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Xiaoming WuBaoguo Sun
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Wentao PengJian Zhang
Aug 15, 2019·Chemical Communications : Chem Comm·Chaoqun WangYi Lv
Jul 2, 2020·Organic & Biomolecular Chemistry·Jie GaoXianfeng Gu
Dec 7, 2018·Chemical Society Reviews·Junji ZhangHe Tian
Jan 17, 2020·ChemPlusChem·Guochen BaoPeter A Tanner
Oct 16, 2020·ChemPlusChem·Stephen J Butler, Katrina A Jolliffe
Jun 16, 2021·Journal of Pharmaceutical and Biomedical Analysis·Jian QiaoDahong Li
Jul 16, 2021·Chemical Communications : Chem Comm·Shiya ChenRonghua Yang
Jul 29, 2021·Chemical Communications : Chem Comm·Xiaofan ZhangHuimin Ma
Aug 13, 2021·Journal of Fluorescence·Rashmi KumariAnil Kumar N V
Sep 11, 2019·Inorganic Chemistry·Katherine R Johnson, Ana de Bettencourt-Dias
Jan 13, 2022·Chemical Communications : Chem Comm·Yanyan ZhaoHuimin Ma

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence resonance
FRET

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.