A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features.

Acta Neuropathologica Communications
Mac Lean P NasrallahJoel M Stein

Abstract

A case of a true dual-genotype IDH-mutant oligoastrocytoma with two different cell types within a single mass in a young woman is presented. Imaging findings of the left frontal infiltrating glioma predicted the two neoplastic components that were identified upon resection. Tissue examination demonstrated areas of tumor with contrasting histologic and molecular features, including specific IDH1, ATRX, TP53, TERT and CIC mutational profiles, consistent with oligodendroglioma and astrocytoma, respectively. The clinical and radiological course over 17 months from first diagnosis included three surgical resections with slow progression of the astrocytic component, and ultimately chemotherapy and radiation treatments were commenced. Reports of the clinical courses for these rare cases of dual-genotype oligoastrocytomas will inform therapy choices, to optimize benefit while minimizing side effects. The steadily increasing number of cases suggests that the neoplasm might be reconsidered as an official entity by the WHO.

References

Oct 13, 2006·Acta Neuropathologica·Mingqi QuZhi-Ping Ren
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Oct 12, 2014·Acta Neuropathologica·Paul WilcoxMichael E Buckland
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Apr 7, 2016·The New England Journal of Medicine·Jan C BucknerWalter J Curran
Dec 13, 2016·Journal of Oncology Practice·Nancy Ann Oberheim Bush, Susan Chang
Jan 28, 2017·AJNR. American Journal of Neuroradiology·D R JohnsonT J Kaufmann
Jul 29, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sohil H PatelRajan Jain
Apr 25, 2018·Acta Neuropathologica·Mitsuaki ShirahataAndreas von Deimling
May 28, 2019·Genome Medicine·Lea F SurreyMarilyn M Li

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Citations

Apr 27, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yukitomo IshiShigeru Yamaguchi

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