A dual radiologic contrast agent protocol for 18F-FDG and 18F-FLT PET/CT imaging of mice bearing abdominal tumors.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Nicolas AideRodney J Hicks

Abstract

The aim of the study was to improve abdominal tumor detection by use of a dual radiologic contrast protocol. eXia160® (Benitio international) was mixed with 2-deoxy-2-[¹⁸F]fluoro-D: -glucose or 3'-[¹⁸F]fluoro-3'-deoxythymidine for intravenous (IV) injections. Omnipaque® 300 (GE healthcare) was used for intraperitoneal (IP) injections. Positron emission tomography/computed tomography (PET/CT) scans were acquired on a Siemens Biograph® equipped with point spread function reconstruction. The optimal concentration and injection schedule of IP contrast agent was studied in 12 mice. The impact of IP contrast media on PET quantitative accuracy was investigated by phantom studies and by imaging six mice before and after IP injection of Omnipaque®. The impact of a dual contrast media protocol on tumor delineation and quantitation was evaluated in 15 tumor-bearing mice using ex vivo counting as the reference. The optimal sequence was a mixture of tracer plus IV contrast agent followed by 1 mL of IP contrast agent (20 mg iodine/mL) administered 10 min before PET/CT acquisition. Phantom studies showed that the use of a 20-mg iodine/mL concentration of Omnipaque® led to a 4.8% overestimation of radioactivity concentration, as compared to sa...Continue Reading

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Citations

Jul 14, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideRodney J Hicks
Aug 25, 2011·AJR. American Journal of Roentgenology·Jing GuPek-Lan Khong
Apr 23, 2013·International Journal of Radiation Oncology, Biology, Physics·Jason CallahanRodney J Hicks

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