A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells

Oncotarget
Miao DingRunsheng Li

Abstract

Androgen deprivation therapy in prostate cancer (PCa) causes neuroendocrine differentiation (NED) of prostatic adenocarcinomas (PAC) cells, leading to recurrence of PCa. Androgen-responsive genes involved in PCa progression including NED remain largely unknown. Here we demonstrated the importance of androgen receptor (AR)-microRNA-204 (miR-204)-XRN1 axis in PCa cell lines and the rat ventral prostate. Androgens downregulate miR-204, resulting in induction of XRN1 (5'-3' exoribonuclease 1), which we identified as a miR-204 target. miR-204 acts as a tumor suppressor in two PAC cell lines (LNCaP and 22Rv1) and as an oncomiR in two neuroendocrine-like prostate cancer (NEPC) cell lines (PC-3 and CL1). Importantly, overexpression of miR-204 and knockdown of XRN1 inhibited AR expression in PCa cells. Repression of miR-34a, a known AR-targeting miRNA, contributes AR expression by XRN1. Thus we revealed the AR-miR-204-XRN1-miR-34a positive feedback loop and a dual function of miR-204/XRN1 axis in prostate cancer.

References

Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·E di SalleA Panzeri
Aug 26, 1999·In Vitro Cellular & Developmental Biology. Animal·R M SramkoskiJ W Jacobberger
May 31, 2003·Molecular Endocrinology·Michael E WrightRuedi Aebersold
Oct 1, 2003·The Prostate·Adrie van BokhovenM Scott Lucia
Jan 2, 2004·Nature Medicine·John T Isaacs, William B Isaacs
Jan 2, 2004·Nature Medicine·Charlie D ChenCharles L Sawyers
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David J Grignon
Aug 4, 2004·Cancer Research·Ren Jie JinRobert J Matusik
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Labile Togba SoumaoroKenichi Sugihara
Jan 22, 2005·European Urology·Nadezda Vashchenko, Per-Anders Abrahamsson
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 8, 2007·Nature·Lin HeGregory J Hannon
Nov 21, 2007·Urologia Internationalis·Luca CindoloAlexandre de la Taille
Oct 7, 2008·Biochemical and Biophysical Research Communications·Yasunori FujitaMasafumi Ito
Nov 1, 2008·International Journal of Cancer. Journal International Du Cancer·Weiqun WangRunsheng Li
Dec 17, 2008·Journal of Hepatology·Lei ChenHong-Yang Wang
Mar 23, 2010·Journal of Translational Medicine·Drazen M JukicMonica C Panelli
Mar 30, 2010·RNA·Sophie BailMegerditch Kiledjian
Sep 17, 2010·Genes & Development·Michael M Shen, Cory Abate-Shen
Feb 24, 2011·Cancer Research·Päivi ÖstlingOlli Kallioniemi
Mar 15, 2011·International Journal of Cancer. Journal International Du Cancer·T K H ChungY F Wong
Mar 25, 2011·The Prostate·Sheng TaiJiaoti Huang
May 25, 2011·BMC Medical Genomics·Laura E PascalAlvin Y Liu
Mar 6, 2012·Endocrine-related Cancer·Hongbing ChenJiaoti Huang
Apr 17, 2012·Human Molecular Genetics·Claire E FletcherCharlotte L Bevan

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Citations

Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tianqi LiRunsheng Li
Mar 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shuo ZhangHui Ren
Mar 21, 2020·Frontiers in Oncology·Ying XiangShuai-Shuai Niu
Jan 19, 2019·Oncology Letters·Norio UshioNaoki Miura
Aug 29, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xueqin SunXiaohui Yu
Nov 21, 2019·International Journal of Molecular Sciences·Julia JansenHermann M Behre
Jun 8, 2015·Endocrine·Mariarosaria BoccellinoMichele Caraglia
Oct 28, 2016·Cancer Chemotherapy and Pharmacology·Xu WangBaojing Ma
Jun 10, 2016·Journal of Human Genetics·Satoko KojimaYukio Naya
Feb 15, 2017·Journal of Experimental & Clinical Cancer Research : CR·Qinghua CaoLiantang Wang
Feb 13, 2018·Oncology Letters·Qiaoli ChenRunsheng Li
May 6, 2019·International Journal of Molecular Sciences·Natalia García-SanchaJavier Cañueto
Mar 27, 2018·Experimental Cell Research·Hedyieh KarbasforooshanGholamreza Karimi

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