A dynamic model of keratinocyte stem cell renewal and differentiation: role of the p21WAF1/Cip1 and Notch1 signaling pathways

The Journal of Investigative Dermatology. Symposium Proceedings
Ryuhei OkuyamaG Paolo Dotto

Abstract

We present here a dynamic model of functional equilibrium between keratinocyte stem cells, transit amplifying populations and cells that are reversibly versus irreversibly committed to differentiation. According to this model, the size of keratinocyte stem cell populations can be controlled at multiple levels, including relative late steps in the sequence of events leading to terminal differentiation and by the influences of a heterogeneous extra-cellular environment. We discuss how work in our laboratory, on the interconnection between the cyclin/CDK inhibitor p21WAF1/Cip1 and the Notch1 signaling pathways, provides strong support to this dynamic model of stem cell versus committed and/or differentiated keratinocyte populations.

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Citations

Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Florian SpörlAchim Kramer
Mar 22, 2007·Journal of the Royal Society, Interface·Tao SunSheila Macneil
Apr 19, 2006·Genes & Development·Bach-Cuc NguyenG Paolo Dotto
Jan 6, 2007·The Journal of Investigative Dermatology·Eva M SchindlerTatiana Efimova
Oct 15, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·R SinghD M Elston
Aug 4, 2004·Seminars in Cancer Biology·Karine Lefort, G Paolo Dotto
Dec 21, 2006·Differentiation; Research in Biological Diversity·Mariana Roesch-ElyPascal Tomakidi
Feb 16, 2008·Biochemical and Biophysical Research Communications·Yuko KatsukiKen-Ichi Katsube
Dec 3, 2014·Ageing Research Reviews·Yan PengBiao Cheng
Jan 9, 2015·Journal of the Royal Society, Interface·Hong ZhangJin Yang
Mar 20, 2004·Developmental Cell·James A Coffman
Dec 15, 2015·Journal of Lipid Research·Minjung ChaeDong Wook Shin
Jul 18, 2009·Nature Reviews. Cancer·G Paolo Dotto
Mar 7, 2014·The Journal of Biological Chemistry·Kamalika SahaRichard L Eckert
May 22, 2009·Cancer Research·Eva M SchindlerTatiana Efimova
Aug 6, 2005·Science·G Paolo Dotto, George Cotsarelis

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