A dynamic model of outer hair cell motility including intracellular and extracellular fluid viscosity

The Journal of the Acoustical Society of America
J A Tolomeo, C R Steele

Abstract

The deformation response of a guinea pig outer hair cell is modeled for mechanical and electrical stimulation up to 25 kHz. The analysis uses a Fourier series technique for a finite length cell surrounded internally and externally by a much larger continuum of viscous fluid. The analytical solution predicts that outer hair cell length changes occur due to applied mechanical or electrical stimulation without significant resonance, characteristic of a highly damped system. The deformation is found to have little attenuation up to a corner frequency of about 2 kHz for long cells and 10 kHz for short cells, in agreement with published experimental results. For electrical loading of 1 mV across the lateral cell wall, deformation for short cells is calculated to be greater than 1 nm for frequencies up to 20 kHz. These results support the proposition that in vivo the outer hair cell modifies the character of basilar membrane deformation on a cycle-by-cycle basis. An estimate of the capability of the cell to supply energy to the basilar membrane is given based on published values of outer hair cell material properties.

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F KalinecB Kachar
Oct 5, 1989·Nature·A J Hudspeth
Nov 1, 1987·The Journal of the Acoustical Society of America·D H Jen, C R Steele
Jan 11, 1985·Science·W E BrownellY de Ribaupierre
May 1, 1995·The Journal of the Acoustical Society of America·J A Tolomeo, C R Steele
Oct 1, 1994·The Journal of the Acoustical Society of America·K H Iwasa
Jul 1, 1993·Journal of Neurophysiology·P DallosB N Evans
Jul 1, 1996·Biophysical Journal·J A TolomeoM C Holley

❮ Previous
Next ❯

Citations

Jun 15, 2006·The Journal of Membrane Biology·A A SpectorR M Raphael
Oct 21, 2005·Journal of the Association for Research in Otolaryngology : JARO·Zhijie LiaoAlexander A Spector
Mar 21, 1998·Hearing Research·S M KhannaC R Steele
Jul 25, 2009·PLoS Computational Biology·Richard D RabbittWilliam E Brownell
Oct 2, 2007·The Journal of the Acoustical Society of America·Zhijie LiaoAlexander A Spector
Jan 20, 2006·The Journal of the Acoustical Society of America·Zhijie LiaoAlexander A Spector
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·G FrankA W Gummer
Jul 17, 2007·Hearing Research·Hailong Li, Kian-Meng Lim
Jul 12, 2001·Annual Review of Biomedical Engineering·W E BrownellA S Popel
Sep 2, 1999·Current Biology : CB·J Ashmore, G S Géléoc
Jun 26, 2001·Biophysical Journal·A A SpectorA S Popel
May 19, 2005·The Journal of the Acoustical Society of America·Zhijie LiaoAlexander A Spector
Apr 23, 1999·The Journal of the Acoustical Society of America·A A SpectorA S Popel
Jan 21, 2000·The Journal of the Acoustical Society of America·A A ParthasarathiA L Nuttall
Mar 30, 2000·The Journal of the Acoustical Society of America·A A Spector
Feb 1, 2003·The Journal of the Acoustical Society of America·Alexander A SpectorAleksander S Popel
Jan 16, 2008·Physiological Reviews·Jonathan Ashmore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of the Acoustical Society of America
Zhijie LiaoAlexander A Spector
The Journal of the Acoustical Society of America
A A SpectorA S Popel
Journal of the Association for Research in Otolaryngology : JARO
Zhijie LiaoAlexander A Spector
Proceedings of the National Academy of Sciences of the United States of America
G FrankAnthony W Gummer
© 2021 Meta ULC. All rights reserved