A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2

Current Biology : CB
Benjamin R HoughtalingSusan Smith

Abstract

Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function independently to regulate telomere length and protect chromosome ends, respectively. Here, we show that TRF1 and TRF2 are linked via TIN2, a previously identified TRF1-interacting protein, and its novel binding partner TINT1. TINT1 localized to telomeres via TIN2, where it functioned as a negative regulator of telomerase-mediated telomere elongation. TIN2 associated with TINT1, and TRF1 or TRF2 throughout the cell cycle, revealing a partially redundant unit in telomeric chromatin that may provide flexibility in telomere length control. Indeed, when TRF1 was removed from telomeres by overexpression of the positive telomere length regulator tankyrase 1, the TIN2/TINT1 complex remained on telomeres via an increased association with TRF2. Our findings suggest a dynamic cross talk between TRF1 and TRF2 and provide a molecular mechanism for telomere length homeostasis by TRF2 in the absence of TRF1.

References

Feb 1, 1990·Molecular and Cellular Biology·T de LangeH E Varmus
May 31, 1990·Nature·C B HarleyC W Greider
Aug 30, 1990·Nature·N D HastieR C Allshire
Dec 8, 1995·Science·L ChongT de Lange
Feb 20, 1997·Nature·B van Steensel, T de Lange
Apr 1, 1997·The EMBO Journal·A BianchiT de Lange
Nov 5, 1997·Nature Genetics·D BroccoliT de Lange
Nov 5, 1997·Nature Genetics·T BilaudE Gilson
Feb 26, 1998·Cell·B van SteenselT de Lange
May 30, 1998·Genes & Development·C I Nugent, V Lundblad
Nov 20, 1998·Science·S SmithT de Lange
Feb 26, 1999·Science·J KarlsederT de Lange
Nov 9, 2000·Current Biology : CB·S Smith, T de Lange
Mar 14, 2001·Trends in Biochemical Sciences·S Smith
Dec 12, 2001·Molecular and Cellular Biology·Brandoch D CookSusan Smith
Feb 14, 2002·Critical Reviews in Oncology/hematology·Meaghan P GrangerJerry W Shay
Mar 30, 2002·Science·Jan KarlsederTitia de Lange
Jul 27, 2002·Science·Richard S Maser, Ronald A DePinho
May 28, 2003·Nature·Diego Loayza, Titia De Lange
Jun 5, 2003·Genes & Development·William ChangSusan Smith
Oct 21, 2003·Molecular Biology of the Cell·Bibo Li, Titia de Lange
Apr 3, 2004·Molecular and Cellular Biology·Blaine N ArmbrusterChristopher M Counter
Apr 22, 2004·The Journal of Biological Chemistry·Matthew S O'ConnorZhou Songyang
May 11, 2004·Nature Genetics·Jeffrey Zheng-Sheng Ye, Titia de Lange
Jun 8, 2004·Nature Cell Biology·Dan LiuZhou Songyang
Jul 3, 2004·Genes & Development·Jeffrey Zheng-Sheng YeTitia de Lange

❮ Previous
Next ❯

Citations

Jan 5, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michele BrunoriVincent Géli
Jul 14, 2005·Chromosoma·Giovanni CenciMaurizio Gatti
Jun 3, 2006·Chromosoma·Nele Hug, Joachim Lingner
Jan 11, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Tobias ElseDavid O Ferguson
Jun 1, 2005·Mechanisms of Ageing and Development·Susan E Swanberg, Mary E Delany
Mar 23, 2011·Cell Research·Dong YangZhou Songyang
Oct 30, 2012·Nature·Jayakrishnan NandakumarThomas R Cech
Nov 26, 2013·Nature Communications·Larissa GrolimundJoachim Lingner
Sep 22, 2007·Nature Reviews. Molecular Cell Biology·Eric Gilson, Vincent Géli
Jan 10, 2013·Nature Reviews. Molecular Cell Biology·Jayakrishnan Nandakumar, Thomas R Cech
Jan 28, 2009·Nature Structural & Molecular Biology·Jaesung LeeVictoria Lundblad
Jul 17, 2007·Nature Structural & Molecular Biology·Dirk HockemeyerGary D Hammer
Oct 30, 2009·The Journal of Biological Chemistry·Kaori K TakaiTitia de Lange
May 4, 2011·The Journal of Biological Chemistry·Dong YangZhou Songyang
Jul 1, 2008·The Journal of Biological Chemistry·Keiji OkamotoYoichi Shinkai
May 10, 2006·Nucleic Acids Research·Susan M Bailey, John P Murnane
Dec 6, 2011·Nucleic Acids Research·Anaïs PouletMarie-Josèphe Giraud-Panis
Aug 20, 2011·Nucleic Acids Research·Kyung H ChoiMichel M Ouellette
Jan 17, 2008·Genes & Development·Maria Pia Longhese
Aug 26, 2011·Genes & Development·Silvia CanudasSusan Smith
Mar 17, 2010·Genes & Development·Arthur J ZaugThomas R Cech
Jun 4, 2008·Molecular and Cellular Biology·Katharine S BarrientosChristopher M Counter
Aug 5, 2009·Molecular and Cellular Biology·Megan F KendellenChristopher M Counter
Jun 15, 2007·Molecular and Cellular Biology·Liuh-Yow ChenZhou Songyang
Oct 29, 2008·Molecular and Cellular Biology·Wilhelm PalmTitia de Lange
Dec 10, 2009·Molecular and Cellular Biology·Tatsuya KibeTitia de Lange
Dec 13, 2006·Molecular and Cellular Biology·Naduparambil K JacobCarolyn M Price
Feb 15, 2012·Molecular and Cellular Biology·Tohru YonekawaChristopher M Counter
Nov 9, 2011·Molecular and Cellular Biology·Monica Bhanot, Susan Smith
Jun 21, 2005·Molecular and Cellular Biology·Jeremy T BunchPeter Baumann
Mar 2, 2006·Molecular and Cellular Biology·Y Jeffrey ChiangRichard J Hodes
Nov 2, 2012·Molekuliarnaia biologiia·N S ZhdanovaN B Rubtsov
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Sheila A Stewart, Robert A Weinberg
Jul 11, 2006·Annual Review of Genetics·Karel RihaDorothy E Shippen
Aug 6, 2008·Annual Review of Genetics·Wilhelm Palm, Titia de Lange
Oct 3, 2008·Genome Biology·Huawei XinZhou Songyang
Nov 17, 2009·Journal of Cell Science·Liana Oganesian, Jan Karlseder
Jun 13, 2009·Cell Structure and Function·Keiji Okamoto, Yoichi Shinkai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.