A dynamic shift of neural network activity before and after learning-set formation

Cerebral Cortex
Chihiro YokoyamaHirotaka Onoe

Abstract

Learning-set (LS) is a property of insight and hypothesis testing characterized by the ability to solve novel problems based on previous experiences with problem solving. However, the neural organization and mechanisms underlying LS remain unclear. To further characterize this process, positron emission tomography (PET) studies with [15O]H2O were performed to measure regional cerebral blood flow (rCBF) during the learning phase of the two-choice visual discrimination task under the LS paradigm in rhesus monkeys. When comparing studies before and after LS formation, the orbitofrontal and lateral prefrontal cortices were differentially activated, and functional connections between these structures and the striatum, which contributes to habit learning, were altered. We conclude that changes in the lateral prefrontal cortex during problem solving may contribute to the executive function of working memory and also inhibit control of a primitive learning system, thereby promoting LS formation.

References

Jun 1, 1987·Scientific American·M Mishkin, T Appenzeller
Aug 1, 1972·Experimental Neurology·B Jones, M Mishkin
Nov 25, 1998·Brain : a Journal of Neurology·M HondaM Hallett
May 5, 1999·Nature·L Tremblay, W Schultz
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·J Fernandez-RuizM Mishkin
Oct 5, 2002·Journal of Neurophysiology·Katsuyuki SakaiRichard E Passingham
Mar 1, 1958·Psychological Review·F RESTLE
Apr 1, 1952·Journal of Comparative and Physiological Psychology·J M WARREN, H F HARLOW
Jun 16, 2004·Behavioural Brain Research·Chihiro YokoyamaYasuyoshi Watanabe
Jan 1, 1949·Psychological Review·H F HARLOW

❮ Previous
Next ❯

Citations

Dec 19, 2009·Experimental Brain Research·Hiroko Mochizuki-KawaiMitsuru Kawamura
Sep 15, 2009·Current Directions in Psychological Science·Eduardo Mercado
Nov 3, 2006·The American Journal of Chinese Medicine·Toshihiro MaenakaTorao Ishida
Jan 13, 2015·Neuroscience Research·Chihiro Yokoyama, Hirotaka Onoe
Aug 24, 2007·Behavioural Brain Research·Geoffrey van der Plasse, Matthijs G P Feenstra
Feb 5, 2008·Neuropsychologia·Henry W ChaseTrevor W Robbins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.