A dynamic transmission model of eastern equine encephalitis virus

Ecological Modelling
Robert S UnnaschThomas R Unnasch

Abstract

Eastern equine encephalitis virus (EEEV) is one of several arthropod-borne viruses (arboviruses) endemic to the United States. Interactions between arthropod (mosquito) vectors and avian amplification host populations play a significant role in the dynamics of arboviral transmission. Recent data have suggested the hypothesis that an increased rate of successful feeding on young-of-the-year (YOY) birds might play a role in the dynamics of EEEV transmission. To test this hypothesis, we developed a model to explore the effect of the interactions of the vectors and avian host populations on EEEV transmission. Sensitivity analyses conducted using this model revealed eleven parameters that were capable of disproportionately affecting the predicted level of EEEV infection in the vertebrate reservoir and vector populations. Of these, four parameters were related to the interaction of the vector with young-of-the-year birds. Furthermore, adult birds could not substitute for young-of-the-year in initiating and maintaining a predicted enzootic outbreak of EEEV. Taken together, the model predicted that young-of-the-year birds play a key role in establishing and maintaining enzootic outbreaks of EEEV.

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Citations

Feb 2, 2008·Vector Borne and Zoonotic Diseases·Gabriel L HamerUriel D Kitron
Sep 2, 2008·Vector Borne and Zoonotic Diseases·Scott R LossJeffrey D Brawn
Aug 8, 2013·Vector Borne and Zoonotic Diseases·Jean-Philippe RocheleauPascal Michel
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Nov 20, 2009·PloS One·Sean P GrahamThomas R Unnasch
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Mar 10, 2012·The American Journal of Tropical Medicine and Hygiene·Sean P GrahamThomas R Unnasch
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