A dynamical systems perspective on chimeric antigen receptor T-cell dosing

Bone Marrow Transplantation
Amir A ToorShahrukh K Hashmi

Abstract

Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. However, the mechanism driving proliferation in CAR T cells is distinct from conventional T cells. As such there are quantitative differences in the antigen response of these engineered cells when compared with conventional T cells. In this perspective paper the logistic equation of growth is used to develop a mathematical basis for understanding the difference between CAR T cell and conventional T cell response to antigen burden.

References

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Oct 23, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stanley R RiddellCarl H June
Jan 15, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeremy MeierAmir A Toor
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Apr 8, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Amir A ToorMichael C Neale
Jul 15, 2015·Trends in Immunology·Shivani Srivastava, Stanley R Riddell
Dec 22, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Badar Abdul RazzaqA A Toor
Apr 26, 2016·The Journal of Clinical Investigation·Cameron J TurtleDavid G Maloney

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Citations

Nov 19, 2020·Journal of Clinical Pharmacology·Anwesha ChaudhuryAndrew M Stein

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Methods Mentioned

BETA
exome sequencing

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