PMID: 11914107Mar 27, 2002Paper

A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses

Clinical Science
B OlmedillaI A Hininger

Abstract

Increased levels of oxidative stress have been implicated in tissue damage and the development of chronic diseases, and dietary antioxidants may reduce the risk of oxidative tissue damage. As part of a European multicentre project, several studies were undertaken with the aim of testing whether the consumption of foods rich in carotenoids reduces oxidative damage to human tissue components. We describe here the serum response of carotenoids and tocopherols upon supplementation with carotenoids from natural extracts (alpha-carotene+beta-carotene, lutein or lycopene; 15 mg/day) and/or with alpha-tocopherol (100 mg/day) in a multicentre, placebo-controlled intervention study in 400 healthy male and female volunteers, aged 25-45 years, from five European regions (France, Northern Ireland, Republic of Ireland, The Netherlands and Spain). Supplementation with alpha-tocopherol increased serum alpha-tocopherol levels, while producing a marked decrease in serum gamma-tocopherol. Supplementation with alpha- + beta-carotene (carotene-rich palm oil) resulted in 14-fold and 5-fold increases respectively in serum levels of these carotenoids. Supplementation with lutein (from marigold extracts) elevated serum lutein (approx. 5-fold), zeaxanth...Continue Reading

Citations

Sep 3, 2013·Archives of Gerontology and Geriatrics·Zesheng ZhangTingting Wang
Apr 12, 2005·Clinical Biochemistry·B Olmedilla-AlonsoI Blanco-Navarro
Apr 8, 2004·Toxicology Letters·Alexandra Alves-Rodrigues, Andrew Shao
Dec 7, 2011·The British Journal of Nutrition·Simone ElgassMridula Chopra
Mar 9, 2012·The British Journal of Nutrition·Marie-Chantal FargesMarie-Paule Vasson
Sep 30, 2003·The British Journal of Nutrition·F GranadoI Blanco
Aug 23, 2006·The British Journal of Nutrition·Jörg SchlattererAndreas Hahn
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emelia A AssarSassan Hafizi
Dec 1, 2006·Regulatory Toxicology and Pharmacology : RTP·F Granado, B Olmedilla
Feb 4, 2014·Oxidative Medicine and Cellular Longevity·Matilde Otero-LosadaJosé Milei
Jan 24, 2015·Journal of Dietary Supplements·Catherine Ulbricht

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