A European Survey on Digestive Perianastomotic Ulcerations, a Rare Crohn-like Disorder Occurring in Children and Young Adults.

Journal of Pediatric Gastroenterology and Nutrition
Chrystele Madrepediatric GETAID group and the ESPGHAN IBD Porto group

Abstract

Digestive perianastomotic ulcerations (DPAU) resembling Crohn disease lesions are long-term complications of intestinal resections, occurring in children and young adults. They are known to be uncommon, severe and difficult to treat. In the absence of recommendations, we performed a large European survey among the members of the ESPGHAN working group on inflammatory bowel disease (IBD) in order to collect the experience of expert pediatric gastroenterologists on DPAU. Fifty-one patients (29 boys and 22 girls) were identified from 19 centers in 8 countries. Most patients were followed after necrotizing enterocolitis (n = 20) or Hirschsprung disease (n = 11). The anastomosis was performed at a median age (interquartile range) of 6 [1-23] months, and first symptoms occurred 39 [22-106] months after surgery. Anemia was the most prevalent symptom followed by diarrhea, abdominal pain, bloating, and failure to thrive. Hypoalbuminemia, elevated CRP, and fecal calprotectin were common. Deep ulcerations were found in 59% of patients usually proximally to the anastomosis (68%). During a median follow-up of 40 [19-67] months, treatments reported to be the most effective included exclusive enteral nutrition (31/35, 88%), redo anastomosis (1...Continue Reading

References

Nov 1, 1992·Archives of Disease in Childhood·A H HamiltonJ W Puntis
Nov 1, 1989·Journal of Pediatric Gastroenterology and Nutrition·R T CouperG G Forstner
Mar 1, 1988·Journal of Pediatric Surgery·K ParasharJ J Corkery
Aug 1, 1995·The Journal of Pediatrics·J M SondheimerR W Tyson
May 16, 2000·The American Journal of Gastroenterology·S T Chari, R F Keate
Jul 1, 2014·Journal of Pediatric Gastroenterology and Nutrition·Fabienne Charbit-HenrionVirginie Colomb
Aug 12, 2014·Journal of Crohn's & Colitis·Marie-Louise FrémondJean-Pierre Hugot
Mar 26, 2015·Journal of Pediatric Gastroenterology and Nutrition·Lee M BassValeria Cohran
Jun 15, 2017·Journal of Pediatric Surgery·Fabio FusaroPaola De Angelis

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