A fabrication method of gold coated colloidosomes and their application as targeted drug carriers

Soft Matter
Qian SunAlexander F Routh

Abstract

Colloidosomes have attracted considerable attention in recent years because of their potential applications in a range of industries, such as food, bioreactors and medicine. However, traditional polymer shell colloidosomes leak low molecular weight encapsulated materials due to their intrinsic shell permeability. Here, we report aqueous core colloidosomes coated with a gold shell, which make the capsules impermeable. The shells can be ruptured using ultrasound. The gold coated colloidosomes are prepared by making an aqueous core capsule with a polymer shell and then adding HAuCl4, surfactant and l-ascorbic acid to form a second shell. We propose to use the capsules as drug carriers. The gold coated colloidosomes demonstrate a low cytotoxicity and after triggering, both encapsulated doxorubicin and broken gold fragments kill cancer cells. In addition, we set up a targeting model by modifying the gold shell colloidosomes using 4,4'-dithiodibutyric acid and crosslinking them with proteins-rabbit immunoglobulin G (IgG). Label-free surface plasmon resonance was used to test the specific targeting of the functional gold shells with rabbit antigen. The results demonstrate that a new type of functional gold coated colloidosome with non...Continue Reading

References

Jun 24, 1992·Journal of Immunological Methods·J E ButlerL A Cantarero
Dec 18, 2001·Advanced Drug Delivery Reviews·Y Qiu, K Park
Aug 15, 2002·International Journal of Pharmaceutics·Gordon Nelson
Jul 1, 2004·Journal of the American Chemical Society·Paul F NobleVesselin N Paunov
Mar 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ming F HsuManuel Marquez
Jun 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Peter J DowdingPhilippe Bouillot
Oct 27, 2005·Journal of the American Chemical Society·Hui WangNaomi J Halas
Mar 21, 2007·Current Opinion in Biotechnology·Claude P Champagne, Patrick Fustier
Aug 7, 2007·Nano Letters·Jin-Woong KimDavid A Weitz
Dec 10, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Huai Nyin Yow, Alexander F Routh
Nov 26, 2009·Journal of the American Chemical Society·Yongdong Jin, Xiaohu Gao
Apr 13, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Malou Henriksen-LaceyYvonne Perrie
Apr 15, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Huai Nyin YowAlexander F Routh
Apr 29, 2010·ACS Applied Materials & Interfaces·Mary M CarusoJeffrey S Moore
Oct 1, 2010·Journal of the American Chemical Society·Saikat MandalKatsuhiko Ariga
Mar 10, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·J S Sander, A R Studart
Apr 6, 2011·Advanced Drug Delivery Reviews·Mihaela DelceaAndré G Skirtach
Oct 19, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Yuanjin ZhaoDavid A Weitz
Apr 19, 2012·ACS Applied Materials & Interfaces·Marcia W PatchanJason J Benkoski
Nov 2, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Polly H R KeenAlexander F Routh
Feb 13, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Polly H R KeenAlexander F Routh
Feb 19, 2015·Small·Maximilian A ZieringerDavid A Weitz
Jun 17, 2015·ACS Applied Materials & Interfaces·James P HitchcockOlivier J Cayre
Mar 24, 2016·ACS Applied Materials & Interfaces·Hui GaoGleb B Sukhorukov
Mar 31, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Qian SunAlexander F Routh
Sep 8, 2017·ACS Applied Materials & Interfaces·Qian SunAlexander F Routh
Sep 4, 1998·Angewandte Chemie·Edwin DonathHelmuth Möhwald

❮ Previous
Next ❯

Citations

Aug 9, 2019·Expert Opinion on Drug Delivery·Qian SunAlexander F Routh
Sep 6, 2020·Polymers·Joanna Szafraniec-SzczęsnySzczepan Zapotoczny
Mar 19, 2020·ACS Applied Materials & Interfaces·Tomasz KubiakZbigniew Rozynek
Nov 18, 2018·ACS Applied Materials & Interfaces·Shane P MeaneyRico F Tabor

❮ Previous
Next ❯

Methods Mentioned

BETA
surface plasmon resonance
biosensor
scanning electron microscopy
X-ray

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Langmuir : the ACS Journal of Surfaces and Colloids
Qian SunAlexander F Routh
ACS Applied Materials & Interfaces
Qian SunAlexander F Routh
Langmuir : the ACS Journal of Surfaces and Colloids
J S Sander, A R Studart
Langmuir : the ACS Journal of Surfaces and Colloids
Polly H R KeenAlexander F Routh
© 2022 Meta ULC. All rights reserved