A facile approach for synthesis of nano-CeO2 particles loaded co-polymer matrix and their colossal role for blood-brain barrier permeability in Cerebral Ischemia

Journal of Photochemistry and Photobiology. B, Biology
Yongtao GaoHonglin Liu

Abstract

A prospective resource of pharmacological treatment of ischemic brains stroke is rapid interference using potential neuroprotective materials. Cerium oxide nanoparticles have been shown to defend against blood brain barrier damage in cerebral ischemic brain stroke. While cerium oxide nanoparticles is highly permeable across the blood-brain barrier and also these nanoparticles are effective antioxidants, due to its ability to either donate or obtain electrons with alternative +3 and +4 valence states. This oxidation state of cerium oxide has shown efficiency in neutralizing generated free radicals in biological systems has been explored action for cerebral ischemic brain stroke. The nanoparticles are encapsulated on the poly-(lactide-co-glycolide)-polyethyleneglycol copolymer matrixes as nanoparticulate delivery vehicles and it can be enhanced brain targeted drug delivery. Furthermore, the results of spectroscopic and microscopic analysis confirmed that peripheral PEG-PLGA co-polymer chains provide excellent reactivity with nanoparticles which might improve the interface bonds of the nanocomposite formation. Mainly, neuroprotective properties of prepared CeO2-PEG/PLGA matrixes with and without nanoparticles are comparatively stu...Continue Reading

Citations

Feb 13, 2019·Reviews in the Neurosciences·Elnaz AmanzadehMaryam Nourbakhshnia
Jan 7, 2021·Expert Opinion on Drug Delivery·Andrea PerrelliSaverio Francesco Retta
Jan 19, 2021·Biomedical Materials·Zheng ZhouChen Jiang
Feb 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yilan XuHeng Zhang
Jan 25, 2020·Drug Discovery Today·Saeideh NozohouriThomas J Abbruscato
Apr 4, 2021·Polymers·Alexander B ShcherbakovVladimir K Ivanov
Apr 24, 2021·Advanced Healthcare Materials·Geoffroy GoujonVirginie Beray-Berthat

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