A facile construction strategy of stable lipid nanoparticles for drug delivery using a hydrogel-thickened microemulsion system

Nanotechnology
Huabing ChenXiangliang Yang

Abstract

We report a novel facile method for preparing stable nanoparticles with inner spherical solid spheres and an outer hydrogel matrix using a hot O/W hydrogel-thickened microemulsion with spontaneous stability. The nanoparticles with average diameters of about 30.0 nm and 100.0 nm were constructed by cooling the hot hydrogel-thickened microemulsion at different temperatures, respectively. We explained the application of these nanoparticles by actualizing the cutaneous delivery of drug-loaded nanoparticles. The in vitro skin permeation studies showed that the nanoparticles could significantly reduce the penetration of model drugs through skin and resulted in their dermal uptakes in skin. The sol-gel process of TEOS was furthermore used in the template of HTM to regulate the particle size of nanoparticles. The coating of silica on the surface of nanoparticles could regulate the penetration of drug into skin from dermal delivery to transdermal delivery. This strategy provides a facile method to produce nanoparticles with long-term stability and ease of manufacture, which might have a promising application in drug delivery.

References

Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
Jul 9, 2002·International Journal of Pharmaceutics·Elena UgazioMaria Rosa Gasco
Jan 14, 2003·Pharmaceutical Research·Norbert Rasenack, Bernd W Müller
Mar 8, 2003·International Journal of Pharmaceutics·S PeltolaA Urtti
Feb 26, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Claudia Valenta, Katharina Schultz
Mar 17, 2004·Advanced Drug Delivery Reviews·Gregor Cevc
Feb 24, 2005·International Journal of Pharmaceutics·Derya Gulsen, Anuj Chauhan
May 3, 2005·Nature Reviews. Drug Discovery·Howard Rosen, Thierry Abribat
Sep 1, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cornelia M Keck, Rainer H Müller
Nov 18, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T HammadyP Hildgen
Nov 22, 2005·Advanced Drug Delivery Reviews·Andrew A Moshfeghi, Gholam A Peyman
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huabing ChenXiangliang Yang
Feb 14, 2006·International Journal of Pharmaceutics·P KocbekJ Kristl
Apr 8, 2006·International Journal of Pharmaceutics·Huabing ChenXiangliang Yang
Jan 27, 2007·Bioconjugate Chemistry·Giovanna MontanaMarta Di Carlo
Feb 9, 2007·International Journal of Pharmaceutics·Waree TiyaboonchaiPinyupa Plianbangchang
Feb 24, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Heike BunjesWalter Richter
Jun 15, 2007·International Journal of Pharmaceutics·Wei-Guo DaiYan-Qiu Song
Jun 16, 2007·International Journal of Pharmaceutics·Huabing ChenXiangliang Yang

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Citations

Sep 14, 2012·International Journal of Nanomedicine·Norazlinaliza SalimHamidon Basri
Sep 5, 2014·Journal of Pharmaceutical Sciences·Yong-Tai ZhangNian-Ping Feng
Dec 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jungang RenGang Cheng
Jul 23, 2013·Clinical and Experimental Reproductive Medicine·Jeong Mook LimSeung Tae Lee
Jan 21, 2015·Nanomedicine·Javier O MoralesFelipe Oyarzun-Ampuero
Aug 29, 2014·International Journal of Toxicology·Christina L BurnettF Alan Andersen

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