A facile one-pot synthesis of starch functionalized graphene as nano-carrier for pH sensitive and starch-mediated drug delivery

Colloids and Surfaces. B, Biointerfaces
Kunping LiuYixiang Duan

Abstract

A fast, green and facile method was developed to prepare starch functionalized graphene nanosheets (starch-GNS) via the reduction of exfoliated graphene oxides by soluble starch, which acted both as a reductant and as a functionalization reagent for capping graphene nanosheets to prevent aggregation. The as-prepared starch-GNS exhibited good biocompatibility, which was deemed crucial for the biomedical application of graphene. Cellular toxicity tests suggested that the starch-GNS was nontoxic to SW-620 cells even at the relatively concentration of 200 μg mL(-1). After the loading of the commonly used anticancer drug hydroxycamptothecin (HCPT) via physisorption on starch-GNS, the HCPT@starch-GNS composite exhibited a high drug loading capacity and was therefore used for cellular imaging and drug delivery studies. Through the nonspecific endocytosis effect, the HCPT@starch-GNS composite was encapsulated into cytoplasm by SW-620 cancer cells. With the double action of an acid microenvironment and the diastase in SW-620 cells, the HCPT@starch-GNS composite showed high toxicity to the SW-620 cells and experienced a pH sensitive as well as a starch-mediated in vitro sustained release process, which had the potential advantage of impr...Continue Reading

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Citations

Aug 19, 2015·The Science of the Total Environment·George Z KyzasDimitra A Lambropoulou
Mar 31, 2016·Nanotoxicology·Neelesh K MehraSrinath Palakurthi
Apr 18, 2016·Advanced Drug Delivery Reviews·Gayong ShimYu-Kyoung Oh
May 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Srinivasarao YaragallaSabu Thomas
May 14, 2016·Journal of Microencapsulation·Wei ZongXiaojun Han
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May 30, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Ozlem ErolMustafa O Guler
Aug 7, 2018·Nano-micro Letters·Thabitha P Dasari ShareenaPaul B Tchounwou
Feb 11, 2021·Journal of Drug Targeting·Mohaddeseh SajjadiSiavash Iravani
Feb 10, 2021·Polymers·María Montserrat Cruz-BenítezCarlos Alberto Gómez-Aldapa
Aug 8, 2018·Ultrasonics Sonochemistry·Lifeng XuXuejun Cui

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