A facile one-step method for preparation of Fe3O4/CS/INH nanoparticles as a targeted drug delivery for tuberculosis

Materials Science & Engineering. C, Materials for Biological Applications
Chili ZhaoChonghua Pei

Abstract

In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release.

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

The Journal of the Medical Society of New Jersey
A M SEBETYG K HAWKINS
The New England Journal of Medicine
E T Stadler, M Steiner
Beiträge zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung
H TRAUTWEIN
© 2022 Meta ULC. All rights reserved