A facile one-step strategy for development of a double network fibrous scaffold for nerve tissue engineering

Nasim GolafshanMohammadhossein Fathi


The aim of this study was to develop a novel double network scaffold composed of polycaprolactone fumarate (PCLF) and eggshell membrane (ESM) (ESM:PCLF) by using the vacuum infiltration method. Compared to ESM, the mechanical properties of double network scaffold were significantly improved, depending on the solvents applied for double network scaffold formation; acetic acid and dichloromethane. Noticeably, the toughness and strength of double network scaffold prepared using acetic acid were significantly improved compared to ESM (26.6 and 25 times, respectively) attributed to the existence of hydrophilic functional groups in acetic acid which made ESM flexible to absorb further PCLF solution. To assess the effect of double network formation on the biological behavior of ESM, the attachment, proliferation and spreading of PC12 cells cultured on the ESM:PCLF scaffolds were evaluated. Results revealed that the number of cells attached on double network ESM:PCLF scaffold were nearly similar to ESM and significantly higher than that of on the tissue culture plate (2.6 times) and PCLF film (1.7 times). It is envisioned that the offered ESM:PCLF double network scaffold might have great potential to develop the constructs for nerve re...Continue Reading


Oct 21, 1998·Microsurgery·K K WangC L Cetrulo
Apr 23, 2003·Poultry Science·T NakanoL Ozimek
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Kyung Mi WooPeter X Ma
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Jun 8, 2006·Journal of Biomedical Materials Research. Part a·Aijun WangXiufang Zhang
Jun 22, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Qun DongNa Wang
Aug 10, 2007·Acta Biochimica Et Biophysica Sinica·Jilie Kong, Shaoning Yu
Jun 20, 2008·Journal of Biomedical Materials Research. Part a·Shen ZhangXuliang Deng
Jan 14, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Jaime Martín, Carmen Mijangos
Nov 26, 2009·Biomaterials·Deniz YucelVasif Hasirci
Jun 4, 2011·International Journal of Biological Macromolecules·K T ShalumonR Jayakumar
Aug 5, 2011·Tissue Engineering. Part B, Reviews·Alexander R NectowDavid L Kaplan
Aug 5, 2011·Biomedical Materials·Molamma P PrabhakaranS Ramakrishna
Dec 7, 2013·The Journal of Bone and Joint Surgery. American Volume·Justin W GriffinD Nicole Deal
May 14, 2014·Biomaterials·Xiaosong GuDavid F Williams
Jun 15, 2014·Biomaterials·Mahshid KharazihaAli Khademhosseini
Jul 1, 2014·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Ahmad Fadzli SulongNor Hazla Mohamed Haflah
Jan 28, 2016·Regenerative Biomaterials·Lingling TianS Ramakrishna
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Mahesh Kumar Sah, Subha Narayan Rath


Apr 18, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhipeng GuGuochao Liao
Aug 9, 2018·Biomedical Materials·Nasim GolafshanMorteza Alehosseini
Sep 19, 2019·Biomedical Materials·Poornima RamburrunViness Pillay
Aug 7, 2018·Nano-micro Letters·Thabitha P Dasari ShareenaPaul B Tchounwou
Aug 17, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Atefeh VafaeiMohammad Karimipour
Jan 28, 2021·Tissue Engineering. Part a·Negar RajabiFilippo Berto
Apr 29, 2021·Macromolecular Bioscience·Wenlin ChuJianshu Li

Related Concepts

Poly(Caprolactone Fumarate)
Hemocompatible Materials
Plasma Membrane
Cell Motility
Cell Survival
Egg Shell
Scanning Electron Microscopy
Nerve Regeneration
Nerve Tissue

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.