A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety

Chemistry Central Journal
Sobhi M GomhaAhmad M Alhajoj

Abstract

Thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. A novel series of thiazoles carrying 1,3,4-thiadiazole core were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbo-thioamide with the appropriate hydrazonoyl chlorides. The structures of the newly synthesized compounds were confirmed based on elemental and spectral analysis as well as their alternative syntheses. The cytotoxic potency of the newly synthesized thiadiazoles was evaluated by their growth inhibitory potency in liver HepG2 cancer cell line. Also, the structure activity relationship was studied. All the newly synthesized compounds were evaluated for their anticancer activity against liver carcinoma cell line (HepG2) using MTT assay. The results revealed that the compounds 12d, 12c, 6g, 18b, 6c, and 6f (IC50 = 0.82, 0.91, 1.06, 1.25, 1.29 and 1.88 µM, respectively) had good antitumor activity against liver carcinoma cell line (HepG2) when compared with the standard drug Doxorubicin (IC50 = 0.72 µM). Graphical abstract A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety.

References

Jul 20, 1992·Journal of Medicinal Chemistry·W C PattB A Steinbaugh
Mar 7, 2006·Bioorganic & Medicinal Chemistry·Joanna Matysiak, Adam Opolski
Jan 24, 2007·European Journal of Medicinal Chemistry·Mahendra ShiradkarRachit Shah
Jun 2, 2007·European Journal of Medicinal Chemistry·Prakash KaregoudarNalilu Sucheta Kumari
Apr 29, 2008·European Journal of Medicinal Chemistry·Anelia Ts MavrovaPavletta Denkova
Feb 27, 2009·Journal of Medicinal Chemistry·Xiao-Long QiuWen-Hwa Lee
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Oct 1, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sobhi M Gomha, Sayed M Riyadh
Apr 11, 2012·International Journal of Molecular Sciences·Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot
Aug 7, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sobhi M Gomha, Khaled D Khalil
Feb 18, 2014·European Journal of Medicinal Chemistry·Danylo KaminskyyRoman Lesyk
Jun 18, 2014·European Journal of Medicinal Chemistry·Sobhi M GomhaAbdelrahman S Mayhoub
Jan 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sobhi M GomhaAbdou O Abdelhamid
Jun 3, 2015·Chemical Biology & Drug Design·Sobhi M GomhaAbdelrahman S Mayhoub
Feb 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yahia Nasser MabkhotTaibi Ben Hadda
Nov 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sobhi M GomhaYahia N Mabkhot

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Citations

Aug 17, 2018·Mini Reviews in Medicinal Chemistry·Swarnagowri Nayak, Santhosh L Gaonkar
Feb 7, 2020·Current Pharmaceutical Design·Maria FesatidouAthina Geronikaki
Nov 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mastoura M EdreesZeinab A Muhammad
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sraa Abu-MelhaMohamad R Abdelaziz
Jan 29, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca-Maria BorceaOvidiu Oniga
Feb 27, 2021·Drug Design, Development and Therapy·Sobhi M GomhaHuda K Mahmoud
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicolae BaranovCorina Cheptea
Sep 19, 2020·Current Topics in Medicinal Chemistry·Zhen ZhangQing-Shan Li

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