A facile synthesis of pyridazinone derivatives under ultrasonic irradiation

Ultrasonics Sonochemistry
Dorina MantuIonel I Mangalagiu

Abstract

A new, efficient and general method for preparation of N-substituted-pyridazinones using ultrasound irradiation is reported. Under ultrasound the reaction time decreases substantially, the yields are high and the reaction conditions are mild. It was noticed that substituents at the 3-(6)-position of pyridazone heterocycle have a substantial influence on the reactivity, while the effect of the substituents at the 1-(2)-position seems to be of minor importance. A comparative study of the reactions performed under ultrasound conditions versus at room temperature has been done.

Citations

Jun 29, 2010·Ultrasonics Sonochemistry·Manouchehr MamaghaniMohammad Reza Taati
Dec 14, 2016·Future Medicinal Chemistry·Jyoti SinghRanju Bansal

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