PMID: 8220890Sep 1, 1993Paper

A facilitatory effect of anti-angiotensin drugs on vagal bradycardia in the pithed rat and guinea-pig

British Journal of Pharmacology
M Rechtman, H Majewski

Abstract

1. In pithed rats, preganglionic vagal nerve stimulation (at 5 Hz) elicited a bradycardia. This bradycardia was potentiated by the angiotensin converting enzyme inhibitor, captopril (1 mg kg-1, i.v.) by about 40%. Subsequent angiotensin II infusion (0.03 micrograms kg-1 min-1) reversed this effect. A similar facilitatory effect was also seen with the angiotensin receptor antagonist, losartan (10 mg kg-1, i.v.). These results suggest a tonic inhibitory effect of endogenous angiotensin II on vagal transmission. 2. The effect of captopril in potentiating vagal bradycardia appears to be at the level of vagal neurones, since the bradycardia elicited by the muscarinic agonist, methacholine was unaffected. 3. After the pithed rats were nephrectomized, captopril had no effect on vagally-induced bradycardia, suggesting that the formation of the endogenous angiotensin II responsible for the effect was dependent on renin release from the kidney. 4. When the sympathetic nerves of the pithed rat were electrically stimulated there was a tachycardia, and this was unaffected by captopril. However, when the sympathetic and vagus nerves were activated concurrently, the resulting tachycardia was inhibited by captopril. 5. In pithed guinea-pigs, c...Continue Reading

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Citations

Jun 1, 1997·Progress in Neurobiology·H ZhuoC J Helke
Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·H MajewskiI F Musgrave
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Anita MehtaRamesh Goyal
May 8, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumiko YamakiYoshio Tanaka
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi

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