PMID: 8612624Mar 1, 1996Paper

A factor derived from polymorphonuclear leukocytes enhances interleukin-1-induced synovial cell collagenase and prostaglandin E2 production in rats

European Journal of Biochemistry
R HashidaY Nagai

Abstract

We found that short-term culture medium and homogenate of casein-induced rat peritoneal polymorphonuclear leukocytes (PMN) markedly induced collagenase and prostaglandin E2 (PGE2) production by normal rat synovial cells and these effects were abrogated by anti-(rat interleukin-1 alpha) (IL-1 alpha) polyclonal antibodies. However, collagenase activity and PGE2 induced by recombinant rat IL-1 alpha were less than those induced by rat PMN culture medium. It was also proved by radioimmunoassay that rat PMN culture medium contains a relatively small amount of IL-1 alpha. The introduction of IL-1 alpha-deleted PMN culture medium and recombinant rat IL-1 alpha together into the synovial cell culture system revealed that IL-1 alpha deleted PMN culture medium has a significant enhancing activity on IL-1 alpha-induced synovial cell collagenase and PGE2 production. This new factor, which was shown to be a negatively charged protein of about 80 kDa, may have important roles in connective tissue destruction and chronic inflammation in diseases such as rheumatoid arthritis.

References

Sep 1, 1990·Annals of the Rheumatic Diseases·C I WestacottP A Dieppe
Mar 1, 1990·Arthritis and Rheumatism·W P Arend, J M Dayer
May 3, 1990·The New England Journal of Medicine·E D Harris
Jan 1, 1990·Immunology Today·F S di Giovine, G W Duff
Jan 15, 1988·Biochemical and Biophysical Research Communications·S KubotaC S Lieber
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Jan 30, 1987·Biochemical and Biophysical Research Communications·K Phadke
Jan 30, 1993·Lancet·K L Sewell, D E Trentham

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Citations

Oct 29, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Anja Finn, Sandra Claudine Oerther

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