A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play

Journal of Affective Disorders
Doug Hyun HanJeffrey S Anderson

Abstract

Individuals who are chronic, compulsive video game players experience an elevated incidence of major depression. Excessive or problematic game play can interact with depression clinically, and may magnify impulsive behavior associated with video gaming. Functional brain imaging was performed during a Wisconsin Card Sorting Test (WCST) task in 42 healthy control and 95 volunteers seeking treatment for compulsive video game playing, including 60 participants without major depression (pure internet gaming disorder, pure IGD) and 35 participants comorbid with major depression (IGD+MDD). In response to the WCST in contrast to fixation, activation was observed in canonical brain attentional networks including bilateral intraparietal sulcus, frontal eye fields, and middle temporal cortical regions as well as dorsolateral prefrontal, inferior parietal and anterior insula, anterior cingulate cortex in all participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus, compared to healthy control participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus and the right parahippocampal gyrus immediately poster...Continue Reading

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Citations

Oct 28, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Beomwoo NamDoug Hyun Han
Oct 17, 2017·Frontiers in Psychiatry·Aviv M Weinstein
May 28, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rajpreet ChahalAmanda E Guyer
Jun 8, 2017·Frontiers in Human Neuroscience·Marc PalausDiego Redolar-Ripoll
Jan 13, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Haijiang YanGuozhen Zhao
Feb 15, 2021·Reviews in the Neurosciences·Bernard J BorserioLinda L Agnew
Aug 17, 2021·Psychiatry Research. Neuroimaging·Whitney N GellerStacie L Warren

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