A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects

Statistical Applications in Genetics and Molecular Biology
Christoph LangeN M Laird

Abstract

We propose a family-based association test, FBAT-PC, for studies with quantitative traits that are measured repeatedly. The traits may be influenced by partially or completely unknown factors that may vary for each measurement. Using generalized principal component analysis, FBAT-PC amplifies the genetic effects of each measurement by constructing an overall phenotype with maximal heritability. Analytically, and in the simulation studies, we compare FBAT-PC with standard methodology and assess both the heritability of the overall phenotype and the power of FBAT-PC. Compared to univariate analysis, FBAT-PC achieves power gains of up to 200%. Applications of FBAT-PC to an osteoporosis study and to an asthma study show the practical relevance of FBAT-PC. FBAT-PC has been implemented in the software package PBAT and is freely available at http://www.biostat.harvard.edu/~clange/default.htm.

Citations

Apr 23, 2009·Human Genetics·Barbara FrankeStephen V Faraone
May 1, 2012·Journal of Probability and Statistics·Qiong Yang, Yuanjia Wang
Sep 24, 2005·American Journal of Respiratory and Critical Care Medicine·Benjamin A RabyScott T Weiss
Jun 12, 2010·American Journal of Respiratory and Critical Care Medicine·Ann Chen WuAugusto A Litonjua
Feb 3, 2006·BMC Genetics·Amy MurphyKristel Van Steen
Dec 4, 2009·PloS One·Lei ZhangHong-Wen Deng
Jun 7, 2005·Nature Genetics·Kristel Van SteenChristoph Lange
May 8, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·J Lasky-Su, C Lange
May 12, 2009·Pediatric Pulmonology·Hara LevyScott T Weiss
Sep 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jessica Lasky-SuStephen V Faraone
Oct 28, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Richard J L AnneyMichael Gill
May 8, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Wai Lun Alan FungDeborah Blacker
Jul 8, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Francesca LantieriMarcella Devoto
Jul 19, 2012·Genetic Epidemiology·Ja-an LinJoseph G Ibrahim
May 19, 2011·Statistics in Medicine·K Van Steen
Mar 19, 2016·Annals of Human Genetics·Zhenchuan WangShuanglin Zhang
Aug 19, 2007·American Journal of Human Genetics·Iuliana Ionita-LazaChristoph Lange
Jul 7, 2009·American Journal of Human Genetics·Amy MurphyJuan C Celedón
Apr 5, 2008·American Journal of Human Genetics·Jessica Lasky-SuChristoph Lange
Mar 8, 2016·PloS One·Zhenchuan WangShuanglin Zhang
Jun 21, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Matthew B McQueenDeborah Blacker
Jun 21, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jessica Lasky-SuStephen Faraone
Jan 21, 2010·European Journal of Human Genetics : EJHG·Jessica Lasky-SuChristoph Lange
Apr 19, 2006·Nature Reviews. Genetics·Nan M Laird, Christoph Lange
Jul 11, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R H PodolskyH Snieder
Aug 27, 2009·European Journal of Human Genetics : EJHG·Sarah Elizabeth Medland, Michael Churton Neale
Oct 27, 2016·European Journal of Human Genetics : EJHG·Shuai WangJosée Dupuis
Jun 12, 2013·Nature Reviews. Genetics·Nadia SolovieffJordan W Smoller
Dec 19, 2009·The New England Journal of Medicine·Gary M HunninghakeJuan C Celedón
Nov 3, 2017·Open Biology·Sophie Hackinger, Eleftheria Zeggini
Nov 20, 2013·Human Heredity·Saonli BasuMatt McGue
Jun 2, 2011·Nature Reviews. Genetics·Jurg OttMark Lathrop

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