A family cluster of streptococcal toxic shock syndrome in children: clinical implication and epidemiological investigation

Pediatrics
Y C HuangS H Hsia

Abstract

Most invasive group A streptococcal (GAS) disease occurs sporadically. Reports of family clusters of these infections are scanty, and most invasive disease occurs in adults. We describe a family cluster of streptococcal toxic shock syndrome (STSS) involving 3 children and present the results of an epidemiologic investigation. During a 16-day period, 3 children in a family developed STSS with an interval of 7 and 9 days, respectively, between the onset of disease. Cases 2 and 3 had GAS isolated from blood culture. Case 2 was fatal. Pharyngeal culture survey of the family members and schoolchildren was conducted. Antibiogram, serotyping, detection of exotoxin genes, and random amplified polymorphic DNA patterns of the disease strains and survey strains were examined. One of 15 family members sampled-the sister of the index case-and 7 (5.6%) of 125 schoolchildren sampled had GAS isolated from pharyngeal cultures. Of the 10 strains examined, 2 isolates from the patients, 1 from the sister of index case, and 2 from the classmates of case 2 (the fatal case) had an identical pattern of both genotype and phenotype. We describe a family cluster of STSS involving 3 children caused by a single clone and provide additional data regarding i...Continue Reading

Citations

Oct 2, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Prevention of Invasive Group A Streptococcal Infections Workshop Participants
Jan 30, 2007·The Pediatric Infectious Disease Journal·Hideaki KikutaKunihiko Kobayashi
Mar 22, 2005·Paediatric Drugs·Yu-Yu ChuangTzou-Yien Lin
Jun 13, 2012·Drugs·Andrew C SteerJonathan R Carapetis
Feb 26, 2016·Journal of the Pediatric Infectious Diseases Society·Rosângela Stadnick Lauth de Almeida TorresPierre R Smeesters
Mar 1, 2008·Expert Opinion on Medical Diagnostics·Andrew C SteerJonathan R Carapetis
Aug 30, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yu-Chia Hsieh, Yhu-Chering Huang
Jun 10, 2014·Journal of Paediatrics and Child Health·Anna LithgowPierre Robert Smeesters

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