A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota

Nature Communications
Michael J CoyneLaurie E Comstock

Abstract

Bacteria often produce antimicrobial toxins to compete in microbial communities. Here we identify a family of broad-spectrum peptide toxins, named bacteroidetocins, produced by Bacteroidetes species. We study this toxin family using phenotypic, mutational, bioinformatic, and human metagenomic analyses. Bacteroidetocins are related to class IIa bacteriocins of Gram-positive bacteria and kill members of the Bacteroidetes phylum, including Bacteroides, Parabacteroides, and Prevotella gut species, as well as pathogenic Prevotella species. The bacteroidetocin biosynthesis genes are found in horizontally acquired mobile elements, which likely allow dissemination within the gut microbiota and may explain their wide distribution in human populations. Bacteroidetocins may have potential applications in microbiome engineering and as therapeutics for polymicrobial diseases such as bacterial vaginosis and periodontal disease.

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Citations

Feb 5, 2021·Gut Microbes·Hassan Zafar, Milton H Saier
Nov 11, 2020·Journal of Bacteriology·Robert W P Glowacki, Eric C Martens
May 7, 2021·Communications Biology·Chrats MelkonianRob J M van Spanning
Jan 21, 2021·Genome Génome / Conseil National De Recherches Canada·Shivakumara Siddaramappa
Jun 3, 2021·Nature Reviews. Microbiology·Simon HeilbronnerAndreas Peschel
Jul 18, 2021·Protein Expression and Purification·Nilam J TulsaniChaitanya G Joshi
Aug 6, 2021·Annual Review of Microbiology·Mariana G SartorioM Florencia Haurat

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Methods Mentioned

BETA
ICE
ICEs
phosphotransferase
PCR

Software Mentioned

Velvet
Sequest
Clustal Omega
MView
MAFFT
BBDuk
Prism
EBLOSUM62
BBTools
EMBOSS

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