PMID: 9448314Mar 14, 1998Paper

A family of chimeric erythrocyte binding proteins of malaria parasites

Proceedings of the National Academy of Sciences of the United States of America
S H KappeJohn H Adams

Abstract

Proteins sequestered within organelles of the apical complex of malaria merozoites are involved in erythrocyte invasion, but few of these proteins and their interaction with the host erythrocyte have been characterized. In this report we describe MAEBL, a family of erythrocyte binding proteins identified in the rodent malaria parasites Plasmodium yoelii yoelii and Plasmodium berghei. MAEBL has a chimeric character, uniting domains from two distinct apical organelle protein families within one protein. MAEBL has a molecular structure homologous to the Duffy binding-like family of erythrocyte binding proteins located in the micronemes of merozoites. However, the amino cysteine-rich domain of MAEBL has no similarity to the consensus Duffy binding-like amino cysteine-rich ligand domain, but instead is similar to the 44-kDa ectodomain fragment of the apical membrane antigen 1 (AMA-1) rhoptry protein family. MAEBL has a tandem duplication of this AMA-1-like domain, and both of these cysteine-rich domains bound erythrocytes when expressed in vitro. Differential transcription and splicing of the maebl locus occurred in the YM clone of P. yoelii yoelii. The apical distribution of MAEBL suggested localization within the rhoptry organelle...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J H AdamsL H Miller
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 1, 1989·Molecular and Cellular Biology·M G PetersonD J Kemp
Apr 1, 1995·Annals of Tropical Medicine and Parasitology·J W Barnwell, M R Galinski
May 1, 1994·Biochemical Society Transactions·A A HolderK A Sinha
Nov 15, 1996·The Journal of Biological Chemistry·A N HodderR F Anders
Sep 23, 1997·Molecular and Biochemical Parasitology·S H KappeJ H Adams

❮ Previous
Next ❯

Citations

Dec 12, 2012·Parasitology Research·Criseyda MartinezRavinder N M Sehgal
Apr 7, 2005·Molecular and Biochemical Parasitology·Jun FuJohn H Adams
Sep 28, 2002·International Journal for Parasitology·Odile Mercereau-PuijalonEmmanuel Bischoff
Mar 25, 2000·International Journal for Parasitology·L H van LinA P Waters
Jun 22, 2002·Molecular and Biochemical Parasitology·Peter L BlairJohn H Adams
Dec 16, 1998·Molecular and Biochemical Parasitology·A R Noe, J H Adams
May 26, 1999·Molecular and Biochemical Parasitology·C A OwenA A Holder
Sep 28, 2000·Parasitology Today·C E Chitnis, M J Blackman
Mar 6, 1999·Current Opinion in Microbiology·K Haldar
Mar 6, 1999·Current Opinion in Microbiology·R L CoppelV Nussenzweig
Mar 20, 2003·Trends in Parasitology·Stefan H I KappeKai Matuschewski
May 22, 2002·The Journal of Experimental Medicine·Tohru KariuYasuo Chinzei
Jun 26, 2002·Molecular Biology and Evolution·Pascal MichonJohn H Adams
Apr 9, 2001·Infection and Immunity·A N HodderR F Anders
May 25, 2004·Infection and Immunity·Peter PreiserJohn H Adams
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Stefan H I KappeVictor Nussenzweig
Jul 7, 2009·Annual Review of Microbiology·Ahmed S I AlyStefan H I Kappe
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·S H KappeV Nussenzweig
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shiho SuzukiShigetou Namba
Jun 10, 2000·The Journal of Eukaryotic Microbiology·R N AnthonyT Y Sam-Yellowe
Jul 17, 2007·Molecular Microbiology·Jayasree IyerPeter R Preiser
Apr 2, 2005·Protein Expression and Purification·Aditi GuptaAdrian H Batchelor
Feb 8, 2005·Molecular and Biochemical Parasitology·M LabbéP Péry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.