A family study of a mother and daughter with increased susceptibility to early-onset periodontitis: microbiological, immunological, host defensive, and genetic analyses

Journal of Periodontology
F NishimuraY Murayama

Abstract

Microbiological, immunological, host-defensive, and genetic analyses were performed on a mother and daughter, both of whom had early-onset periodontitis (rapidly progressive periodontitis in the mother; localized juvenile periodontitis in the daughter). Microscopic examination revealed a greatly elevated percentage of rod-form bacteria in both subjects. Fusobacterium sp. and Porphyromonas gingivalis (formerly Bacteroides gingivalis) were the predominant microorganisms cultured. The humoral immune responses to F. nucleatum, P. gingivalis, and Actinobacillus actinomycetemcomitans were much higher in both subjects than those to any other periodontal bacteria examined. Functional and phenotypic analysis of the peripheral lymphocytes showed no significant abnormalities. However, investigation of neutrophil function showed that the mother had depressed neutrophil chemotaxis and superoxide production. The daughter had depression not only of chemotaxis and superoxide production, but also of neutrophil phagocytosis. Serological typing of HLA antigens revealed the same Class II HLA profile in both subjects. It was concluded that both subjects very probably had an identical condition and that these patients provided a unique model for imp...Continue Reading

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Citations

Nov 9, 2002·Journal of Clinical Periodontology·Gülnur EmingilFerda Ozkinay
Apr 11, 2014·The Bulletin of Tokyo Dental College·Rie FujiiMasahiro Furusawa
Dec 25, 2015·The Journal of Evidence-based Dental Practice·Ahmed Yaseen Alqutaibi, Radhwan Saleh Algabri
Apr 20, 2011·Periodontology 2000·Huanxin MengZhibing Chen
Jan 14, 2011·Journal of Clinical Periodontology·Noriyoshi MizunoHidemi Kurihara
Sep 20, 2015·Clinical Oral Implants Research·Stefan Renvert, Marc Quirynen
Jun 21, 2008·FEMS Immunology and Medical Microbiology·Junko MiyagawaShogo Takashiba
Sep 2, 1998·Annals of Periodontology·F NishimuraY Murayama
Nov 1, 1996·Annals of Periodontology·J J Zambon
Feb 1, 1994·Journal of Periodontology·K TakahashiY Murayama
May 8, 2001·Journal of Periodontology·K TakahashiY Murayama
Jun 23, 2000·Annals of Periodontology·M S Tonetti, A Mombelli
Feb 1, 2005·FEMS Immunology and Medical Microbiology·Hiroshi MaedaShogo Takashiba
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T M Hassell, E L Harris
Jan 10, 2006·Periodontology 2000·Shogo Takashiba, Koji Naruishi
Jun 1, 1996·Journal of Clinical Periodontology·E FiratliO Tuncer
Jul 17, 2001·Periodontology 2000·I Darby, M Curtis
Oct 1, 1994·Periodontology 2000·H A Schenkein, T E Van Dyke
May 20, 2020·Journal of Human Genetics·Noriyoshi MizunoHidemi Kurihara
Aug 1, 1995·The Journal of the American Dental Association·H A SchenkeinJ G Tew

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