A family study of congenital inguinal hernia

American Journal of Medical Genetics
A Czeizel, J Gárdonyi

Abstract

In fathers and mothers of 707 index patients with operated indirect congenital inguinal hernia (CIH) born in Budapest during the years 1962-1966 the frequency of CIH was two and five to six times higher, respectively, than in the general population. The rate of affected sibs was higher than that of parents but was greatly dependent on the sex of the index patient. Heritability estimates of CIH vary significantly in parents (0.35 +/- 0.12) and in sibs (0.78 +/- 0.14). In twins the heritability is 0.77. These data agree with the multifactorial threshold model involving dominance variance.

References

Jan 1, 1976·Human Heredity·A CzeizelA Molnár
Jan 1, 1969·British Medical Bulletin·C O Carter
Jan 6, 1962·British Medical Journal·A G MARSHALLJ HONISETT
Aug 1, 1949·The Journal of Heredity·B R WEIMER

❮ Previous
Next ❯

Citations

Mar 1, 1981·European Journal of Pediatrics·A Czeizel, M Mészáros
Feb 21, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J BurcharthJ Rosenberg
Mar 1, 1994·Journal of Medical Genetics·Y GongY Guo
Apr 4, 2006·The Surgical Clinics of North America·Jeffrey H Haynes
Dec 10, 2009·Pharmacoepidemiology and Drug Safety·János GidaiAndrew E Czeizel
Feb 13, 2008·The Surgical Clinics of North America·Mary L Brandt
Feb 1, 2007·Surgery·Hung LauNivritti G Patil
Jul 5, 2005·The Lancet Oncology·Patricia C ValeryChris Bain
May 11, 2012·Korean journal of pediatrics·Yu Mi ChoiHyun Cheol Kim
May 27, 2003·International Journal of Cancer. Journal International Du Cancer·Patricia Casarolli ValeryChris Bain
Nov 5, 2010·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jan PraskoKlara Latalova
Oct 1, 1981·The Journal of Urology·A CzeizelJ Tóth
Apr 27, 2019·Frontiers in Surgery·Hakan Kulacoglu, Ferdinand Köckerling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Progress in Neuro-psychopharmacology & Biological Psychiatry
Yong-Ku Kim
Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a
Torbjörn BackmanCarl M Kullendorff
© 2021 Meta ULC. All rights reserved