A Fas(hi) Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation

Frontiers in Immunology
Soraya Maria MenezesJohan Van Weyenbergh

Abstract

Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been associated to both ATL and HAM/TSP susceptibility. Fas(hi) T stem cell memory (Tscm) cells have been identified as the hierarchical apex of ATL, but have not been investigated in HAM/TSP. In addition, both FAS and STAT1 have been identified in an IFN-inducible HAM/TSP gene signature, but its pathobiological significance remains unclear. We comprehensively explored Fas expression (protein/mRNA) and function in lymphocyte activation, apoptosis, proliferation, and transcriptome, in PBMC from a total of 47 HAM/TSP patients, 40 asymptomatic HTLV-1-infected individuals (AC), and 58 HTLV-1 -uninfected healthy controls. Fas surface expression followed a two-step increase from HC to AC and from AC to HAM/TSP. In HAM/TSP, Fas levels correlated positively to lymphocyte activation markers, but negatively to...Continue Reading

References

Mar 1, 1994·The Journal of Experimental Medicine·T Suda, S Nagata
Dec 1, 1996·Journal of Neuroimmunology·H IchikawaM Iwata
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Oct 26, 2000·Nature·P H Krammer
Jan 17, 2002·The Journal of Pathology·Tineke TimmerSteven de Jong
May 23, 2002·The Journal of Infectious Diseases·Rosangela G LimaDumith Chequer Bou-Habib
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janeusa PrimoAchiléa L Bittencourt
Sep 13, 2005·Oncogene·Charles R M Bangham, Mitsuhiro Osame
Mar 23, 2007·The Lancet Infectious Diseases·Kristien VerdonckEduardo Gotuzzo
Sep 7, 2007·Annals of the New York Academy of Sciences·Anat AchironMichael Gurevich
Jan 5, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lourdes FarreAchiléa L Bittencourt
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Daniela SaggioroVincenzo Ciminale
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Karen L WoodAndrea I Doseff
Sep 20, 2011·Nature Medicine·Luca GattinoniNicholas P Restifo
Oct 15, 2011·Blood·Stéphane OlindoLuc Willems
Apr 17, 2012·Autoimmunity Reviews·C ComiU Dianzani
Nov 20, 2012·Frontiers in Microbiology·Antoine Gessain, Olivier Cassar
Jul 23, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Olga BarcaVíctor M Arce
Mar 31, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Davi TanajuraEdgar M Carvalho
Mar 31, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Graham P Taylor
Apr 8, 2015·Blood·Yuya NagaiAkifumi Takaori-Kondo
Jan 1, 2015·Nature Reviews. Disease Primers·Charles R M BanghamGraham P Taylor

Citations

Nov 18, 2018·Frontiers in Immunology·Jesse W WilliamsAnne I Sperling
Aug 28, 2019·International Journal of Molecular Sciences·Giovanna C CavalcanteÂndrea Ribeiro-Dos-Santos
Jan 31, 2018·Frontiers in Microbiology·Antonio C R VallinotoRicardo Ishak
Apr 12, 2021·Neurology. Clinical Practice·Gabriela PratesJorge Casseb

Datasets Mentioned

BETA
GSE82160

Methods Mentioned

BETA
ELISA
density gradient centrifugation
flow cytometry
fluorescence
fluorescence microscopy

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