A fast algorithm aligning multiple microbial genomic sequences

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Guangyue Hu, Shiyi Shen


To compare large genomic DNA sequences of related organisms and of different species, researchers need efficient methods to align many long sequences. We developed a new tool Super Multiple Genome Alignment (SMGA for short), specially for rapid multiple global alignment of genomic sequences. SMGA can align a data set consisting of 50M of 9 enterobacterial genomic sequences in 40 minutes. Our method is faster when compared with other existing multiple sequences alignment method.

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