A fast algorithm for estimating transmission probabilities in QTL detection designs with dense maps.

Genetics, Selection, Evolution : GSE
Jean-Michel ElsenCarole Moreno

Abstract

In the case of an autosomal locus, four transmission events from the parents to progeny are possible, specified by the grand parental origin of the alleles inherited by this individual. Computing the probabilities of these transmission events is essential to perform QTL detection methods. A fast algorithm for the estimation of these probabilities conditional to parental phases has been developed. It is adapted to classical QTL detection designs applied to outbred populations, in particular to designs composed of half and/or full sib families. It assumes the absence of interference. The theory is fully developed and an example is given.

References

Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·E S Lander, D Botstein
Nov 20, 2001·Genetics, Selection, Evolution : GSE·R Pong-WongC S Haley
Dec 18, 2002·Genetics, Selection, Evolution : GSE·Yuefu LiuChing Y Lin
Oct 15, 2013·G3 : Genes - Genomes - Genetics·Ronald M NelsonOrjan Carlborg
Jul 1, 1996·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·S A KnottC S Haley

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Citations

Jul 11, 2012·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M K Wais, J M Elsen
Aug 13, 2015·PloS One·Sandrine Mignon-GrasteauIrène Gabriel
Sep 28, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·C A García-BaccinoR J C Cantet
Apr 13, 2010·BMC Proceedings·Olivier DemeurePascale Le Roy
Jan 23, 2016·Genetics, Selection, Evolution : GSE·Marina AtlijaBeatriz Gutiérrez-Gil

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Software Mentioned

centiMorgan
INRA
QTLMap

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