A fast field-cycling device for high-resolution NMR: Design and application to spin relaxation and hyperpolarization experiments

Journal of Magnetic Resonance
Alexey S KiryutinAlexandra V Yurkovskaya

Abstract

A device for performing fast magnetic field-cycling NMR experiments is described. A key feature of this setup is that it combines fast switching of the external magnetic field and high-resolution NMR detection. The field-cycling method is based on precise mechanical positioning of the NMR probe with the mounted sample in the inhomogeneous fringe field of the spectrometer magnet. The device enables field variation over several decades (from 100μT up to 7T) within less than 0.3s; progress in NMR probe design provides NMR linewidths of about 10(-3)ppm. The experimental method is very versatile and enables site-specific studies of spin relaxation (NMRD, LLSs) and spin hyperpolarization (DNP, CIDNP, and SABRE) at variable magnetic field and at variable temperature. Experimental examples of such studies are demonstrated; advantages of the experimental method are described and existing challenges in the field are outlined.

References

Aug 14, 1998·Physics in Medicine and Biology·T Guiberteau, D Grucker
Mar 29, 2001·Journal of Magnetic Resonance·O LipsF Fujara
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mary F Roberts, Alfred G Redfield
Apr 19, 2005·Magnetic Resonance Imaging·Robert G Bryant, Jean-Pierre Korb
Oct 21, 2006·Science·Leif SchröderAlexander Pines
Feb 1, 2007·Journal of the American Chemical Society·Claudio Luchinat, Giacomo Parigi
Feb 13, 2008·The Journal of Chemical Physics·Thorsten MalyRobert G Griffin
Apr 22, 2008·Solid State Nuclear Magnetic Resonance·Alexey KiryutinHans-Martin Vieth
Oct 2, 2009·Physical Review Letters·Giuseppe PileioMalcolm H Levitt
May 13, 2010·Physical Chemistry Chemical Physics : PCCP·Alexander KrahnChristian Griesinger
Mar 12, 2011·Journal of Magnetic Resonance·Pascal MiévilleGeoffrey Bodenhausen
Apr 8, 2011·Journal of the American Chemical Society·Michael J CowleyRyan E Mewis
Jan 10, 2012·Annual Review of Physical Chemistry·Malcolm H Levitt
Mar 30, 2012·Physical Chemistry Chemical Physics : PCCP·Egor A NasibulovHans-Martin Vieth
May 2, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·D KrukE A Rössler
May 15, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·C GriesingerT F Prisner
May 19, 2012·Journal of Magnetic Resonance·L BuljubasichK Münnemann
Oct 30, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Richard A GreenGary G R Green
Jul 31, 2013·Physical Chemistry Chemical Physics : PCCP·Andrey N PravdivtsevKonstantin L Ivanov
Aug 21, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Andrey N PravdivtsevRobert Kaptein
Nov 16, 2013·Journal of the American Chemical Society·Cyril CharlierFabien Ferrage
Mar 19, 2014·Physical Chemistry Chemical Physics : PCCP·Andrey N PravdivtsevKonstantin L Ivanov
Mar 25, 2014·Journal of Magnetic Resonance·Jung Ho LeeSilvia Cavagnero
May 8, 2014·Magnetic Resonance in Chemistry : MRC·Ryan E MewisDavid C Williamson
Jun 20, 2014·Journal of the American Chemical Society·Olga TorresDavid C Williamson
Aug 22, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Konstantin L IvanovRobert Kaptein
Dec 3, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Franz FujaraAlexei F Privalov
May 9, 2015·Journal of Magnetic Resonance·Seong-Joo LeeSeong-min Hwang

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Citations

Nov 29, 2016·Physical Chemistry Chemical Physics : PCCP·Samuel F CousinFabien Ferrage
Feb 28, 2018·Angewandte Chemie·Jan-Bernd HövenerEduard Y Chekmenev
Oct 18, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Olga B Morozova, Konstantin L Ivanov
Dec 7, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ludmilla GuduffGaspard Huber
Feb 3, 2019·The Review of Scientific Instruments·A AjoyA Pines
Sep 21, 2017·Scientific Reports·Shubhajit PaulXiaojie Wang
Jul 16, 2016·Angewandte Chemie·Samuel F CousinFabien Ferrage
Jul 11, 2020·Journal of Magnetic Resonance·Andrew M R HallGiuseppe Pileio
Apr 8, 2021·Magnetic Resonance in Chemistry : MRC·John W BlanchardDmitry Budker
Jun 26, 2021·Physical Chemistry Chemical Physics : PCCP·Andrey N PravdivtsevJan-Bernd Hövener
Jul 30, 2021·The Journal of Physical Chemistry. B·Mary F RobertsAlfred G Redfield
Feb 27, 2021·Angewandte Chemie·Andrey N PravdivtsevJan-Bernd Hövener
Sep 12, 2019·The Journal of Physical Chemistry Letters·Pavel KadeřávekFabien Ferrage

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