A fast-multiclass method for the determination of 21 endocrine disruptors in human urine by using vortex-assisted dispersive liquid-liquid microextraction (VADLLME) and LC-MS/MS

Environmental Research
Mariana Zuccherato BocatoFernando Barbosa

Abstract

Simplicity, speed, and reduced cost are essential demands for routine analysis in human biomonitoring studies. Moreover, the availability of higher volumes of human specimens is becoming more restrictive due to ethical controls and to the costs associated with sample transportation and storage. Thus, analytical methods requiring much lower sample volumes associated with simultaneous detection capability (multiclass analysis) are with a very high claim. In this sense, the present approach aimed at the development of a method for preconcentration and simultaneous determination of four classes of endocrine disruptors (seven bisphenols, seven parabens, five benzophenones, and two antimicrobials) in the urine. The approach is based on vortex-assisted dispersive liquid-liquid microextraction (VADLLME) and high-performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). After optimization of the significant parameters of VADLLME extraction, the proposed procedure showed to be simple, fast, sensitive, requiring only 1.0 mL of urine, 400 μL of organic solvents with a total stirring time of 20 s. Moreover, a variation of inter-day and between-day runs were lower than 10.0% and 11.0%, respectively. Finally, the propo...Continue Reading

References

Jun 22, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·A M AlmeidaA C Falcão
Apr 1, 2006·Journal of Chromatography. a·Mohammad RezaeeSana Berijani
Mar 16, 2012·Environmental Science & Technology·Tatsuya KunisueKurunthachalam Kannan
Nov 22, 2013·Analytical and Bioanalytical Chemistry·Mohammad Saraji, Malihe Khalili Boroujeni
Jan 28, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lucas DewalqueCorinne Charlier
Jan 7, 2015·Critical Reviews in Analytical Chemistry·Parinya PanuwetDana Boyd Barr
Aug 9, 2015·Fertility and Sterility·Germaine M Buck LouisKurunthachalam Kannan
Apr 21, 2016·The Science of the Total Environment·I Jiménez-DíazN Olea
May 5, 2016·Environmental Science & Technology·Da ChenMargaret Widelka
Jun 29, 2016·Oncology Reports·Lino Del PupMassimiliano Berretta
Mar 9, 2017·Environmental Health : a Global Access Science Source·Jennifer PrzybylaMolly L Kile
Mar 16, 2017·Environmental Toxicology and Pharmacology·Stavros SifakisDemetrios A Spandidos
Jul 26, 2017·Talanta·Lucie Kolatorova SosvorovaRichard Hampl
Aug 29, 2017·Reproductive Toxicology·Marya GhazipuraTanzib Hossain
Nov 29, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Lisa M Weatherly, Julie A Gosse
Jul 18, 2018·International Journal of Medical Sciences·Kok-Yong ChinWun Fui Mark-Lee
Oct 6, 2018·Rapid Communications in Mass Spectrometry : RCM·Sung-Hee Cho, Han-Na Song
Feb 20, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Daniel BuryHolger M Koch
Mar 26, 2019·The Science of the Total Environment·Muhammad Bilal, Hafiz M N Iqbal
May 3, 2019·Journal of Analytical Toxicology·Thomas P van der MeerJana V van Vliet-Ostaptchouk
Sep 24, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mariana Zuccherato BocatoFernando Barbosa

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