A faster PISTOL for 1 H MR-based quantitative tissue oximetry

NMR in Biomedicine
Rohini Vidya Shankar, Vikram D Kodibagkar

Abstract

Quantitative mapping of oxygen tension (pO2 ), noninvasively, could potentially be beneficial in cancer and stroke therapy for monitoring therapy and predicting response to certain therapies. Intracellular pO2 measurements may also prove useful in tracking the health of labeled cells and understanding the dynamics of cell therapy in vivo. Proton Imaging of Siloxanes to map Tissue Oxygenation Levels (PISTOL) is a relatively new oximetry technique that measures the T1 of administered siloxanes such as hexamethyldisiloxane (HMDSO), to map the tissue pO2 at various locations with a temporal resolution of 3.5 minutes. We have now developed a siloxane-selective Look-Locker imaging sequence equipped with an echo planar imaging (EPI) readout to accelerate PISTOL acquisitions. The new tissue oximetry sequence, referred to as PISTOL-LL, enables the mapping of HMDSO T1 , and hence tissue pO2 in under one minute. PISTOL-LL was tested and compared with PISTOL in vitro and in vivo. Both sequences were used to record dynamic changes in pO2 of the rat thigh muscle (healthy Fischer rats, n = 6), and showed similar results (P > 0.05) as the other, with each sequence reporting a significant increase in pO2 (P < 0.05) under hyperoxia compared with...Continue Reading

References

Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P Gowland, P Mansfield
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Sep 15, 2004·NMR in Biomedicine·Bernard GallezBénédicte F Jordan
Feb 14, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai-Hsiang Chuang, Alan Koretsky
Mar 1, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vikram D KodibagkarRalph P Mason
Jun 6, 2006·British Journal of Anaesthesia·J Nortje, A K Gupta
Mar 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Vincent A BourkeRalph P Mason
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Vikram D KodibagkarRalph P Mason
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bénédicte F JordanBernard Gallez
Feb 11, 2009·The Journal of Trauma·Jennifer J WanGeoffrey T Manley
Sep 23, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Deepak K K KadayakkaraEric T Ahrens
Oct 5, 2010·NMR in Biomedicine·Caroline DiepartBernard Gallez
Mar 18, 2011·NMR in Biomedicine·Praveen K GulakaVikram D Kodibagkar
Mar 19, 2011·Neurocritical Care·Baxter B AllenJeffrey P Greenfield
May 25, 2011·Nature Reviews. Cancer·William R Wilson, Michael P Hay
Jun 21, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Siyuan LiuMark D Rollins
Jan 5, 2012·PloS One·Philipp Boehm-SturmTherése Kallur
May 24, 2012·Journal of Neurotrauma·Christopher BeynonOliver W Sakowitz
Feb 6, 2013·Theranostics·Jyothi U MenonVikram D Kodibagkar
Sep 10, 2013·Nature Reviews. Immunology·Eric T Ahrens, Jeff W M Bulte
Nov 28, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Praveen K GulakaVikram D Kodibagkar
Jan 24, 2015·Stroke; a Journal of Cerebral Circulation·Nadeem KhanHarold M Swartz
Oct 20, 2015·Methods in Enzymology·Nadeem KhanPeriannan Kuppusamy
Nov 26, 2015·Annals of Biomedical Engineering·Caroline P AddingtonVikram D Kodibagkar
Mar 10, 2016·Neurophotonics·François MoreauJeff F Dunn

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Citations

Jan 31, 2020·Scientific Reports·Shubhangi AgarwalVikram D Kodibagkar
Jul 18, 2020·Transplantation·Alban LongchampFrancois Lazeyras

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