A Fatal Case of Pentedrone and α-Pyrrolidinovalerophenone Poisoning

Journal of Analytical Toxicology
Marzena SykuteraElżbieta Bloch-Boguslawska

Abstract

We report a fatal case of combined α-pyrrolidinovalerophenone (α-PVP) and 2-(methylamino)-1-phenylpentan-1-one (pentedrone) poisoning. A 28-year-old man was taken to hospital in asystole. Despite resuscitation efforts over 30 min, he died. The forensic autopsy showed pulmonary edema and moderately advanced atherosclerotic lesions of the arteries. Microscopic observation revealed chronic changes in the heart. Confirmation of the presence of pentedrone, α-PVP, and its metabolite 1-phenyl-2-(pyrrolidin-1-yl)pentan-1-ol (OH-α-PVP) in tissues and fluids were achieved using gas chromatography-mass spectrometry analysis after liquid-liquid extraction. A quantitative validated liquid chromatography-mass spectrometry method was used to determine the concentrations of the above designer drugs in postmortem samples. Pentedrone, α-PVP, and OH-α-PVP concentrations were 8,794, 901 and 185 ng/mL in whole blood, respectively; 100,044, 2,610 and 2,264 ng/g in the liver, respectively; 22,102, 462 and 294 ng/g in the kidney, respectively; 13,248, 120 and 91 ng/g in the brain, respectively and 500,534, 4,190 and 47 ng/g in the stomach contents, respectively. This is the first known reported death attributed to the combined use of α-PVP and pentedr...Continue Reading

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Citations

May 18, 2016·Journal of Analytical Toxicology·Trista Haupt Wright, Chad Harris
May 27, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Rimako UmebachiSadaki Inokuchi
Jun 4, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Maria João ValenteMárcia Carvalho
Jul 14, 2016·Journal of Analytical Toxicology·Carole JameyJean-Sébastien Raul
Jul 15, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Olof BeckAnders Helander
Oct 12, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Shane V Cherry, Yiliam F Rodriguez
Jul 26, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sara OdoardiSabina Strano-Rossi
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Apr 11, 2019·Psychopharmacology·Katherine R BonsonDominic Chiapperino
Sep 20, 2019·Substance Abuse Treatment, Prevention, and Policy·Patrizia VerriEnrico Silingardi
Oct 17, 2017·Journal of Analytical Toxicology·Yuji FujitaYoshihiro Inoue
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Feb 8, 2021·Archives of Toxicology·Rita Roque BravoDiana Dias da Silva
Nov 4, 2017·Pharmacology & Therapeutics·Laura HondebrinkRemco H S Westerink
Jun 9, 2021·Archives of Toxicology·Jorge SoaresJoão Paulo Capela

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