Abstract
Alprazolam is one of the most widely prescribed benzodiazepines in the United States. It is generally considered a safe and effective drug for the treatment of anxiety disorders and panic attacks. Few overdoses that are due to the sole ingestion of alprazolam have been reported. This paper documents a fatality due to alprazolam intoxication and describes the distribution of alprazolam and an active metabolite, alpha-hydroxyalprazolam, in tissues obtained at autopsy. Qualitative identification of the drugs was achieved by full-scan gas chromatography-mass spectrometry, and quantitative analysis was performed by high-performance liquid chromatography. High concentrations of alprazolam were found in all specimens analyzed, but the metabolite was detected only in subclavian blood, urine, bile, and liver. A postmortem heart blood alprazolam concentration of 2.1 mg/L is the highest reported in the literature to date.
Citations
Jan 22, 2000·Forensic Science International : Synergy·K MichaudP Mangin
Jan 30, 2002·Journal of Pharmaceutical and Biomedical Analysis·M M Hefnawy
May 1, 2013·The American Journal of Forensic Medicine and Pathology·D Kimberley Molina, Veronica M Hargrove
Jan 17, 2016·Forensic Science International : Synergy·F BévalotL Fanton
Jan 31, 2012·Forensic Science International : Synergy·Eunyoung HanSangki Lee
Jan 23, 2016·Forensic Toxicology·Fabien BévalotJérôme Guitton
Apr 29, 2015·Laboratory Medicine·Thomas KampfrathDayong Lee
Jul 17, 2007·Journal of Forensic and Legal Medicine·Einosuke TanakaKatsuya Honda
Jun 29, 2013·The American Journal on Addictions·Neel A ShahDavid J Clay
Jun 3, 2004·Forensic Science International : Synergy·F MusshoffB Madea
Mar 19, 2014·Drug and Alcohol Dependence·Shane DarkeJohan Duflou
Feb 24, 2005·The American Journal of Forensic Medicine and Pathology·Barbara C WolfLisa M Flannagan
Dec 22, 2012·Journal of Psychopharmacology·Alan Wayne Jones, Anita Holmgren
Jun 23, 2004·British Journal of Clinical Pharmacology·Geoffrey K IsbisterIan M Whyte
Jun 18, 2019·Drug Testing and Analysis·Raimo A Ketola, Pirkko Kriikku
Oct 21, 1998·Therapeutic Drug Monitoring·A D Fraser
Aug 19, 2020·Journal of Analytical Toxicology·Szabolcs SofalviLuigino G Apollonio
Jun 17, 2020·Journal of Analytical Toxicology·Donna M PapsunBarry K Logan
Dec 4, 2020·Prague Medical Report·Jana HořínkováOndřej Slanař
Jun 29, 1999·Analytical Chemistry·T A BrettellR Saferstein