A fatality involving 1,3-propanediol and its implications in measurement of other glycols

Journal of Analytical Toxicology
Uttam GargDavid Cathcart

Abstract

The decomposed body of a 45-year-old female was found, face down, in a mobile home, along with a suicide note and two antifreeze containers. Analysis of the body fluid collected from the decedent showed the presence of 58 mg/dL ethanol, but suspected ethylene glycol was not found in the sample. However, an unusually large peak of internal standard, 1,3-propanediol, was found in the sample. Gas chromatography-mass spectrometry analysis confirmed the presence of 1,3-propanediol in the sample. Using gas chromatography-flame-ionization detection, the concentration of 1,3-propanediol was determined to be 445 mg/dL. To our knowledge, this is the first report involving 1,3-propanediol as the cause of death. The study also highlights the importance for the close scrutiny of data, as 1,3-propanediol is a frequently used internal standard for the assay of glycols.

Citations

Sep 5, 2014·Journal of Analytical Toxicology·Laurent ImbertChristian Lacroix
Nov 17, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·William H Porter
May 9, 2009·Analytical Chemistry·T A BrettellJ R Almirall

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