A Feasibility Study of the Full Outpatient Conduction of Hematopoietic Transplants in Persons with Multiple Sclerosis Employing Autologous Non-Cryopreserved Peripheral Blood Stem Cells

Acta Haematologica
Guillermo J Ruiz-ArgüellesGuillermo J Ruiz-Delgado

Abstract

With the goal of achieving immune system reset, autologous hematopoietic stem cell transplantations have been performed in patients with multiple sclerosis (MS). Two hundred and eighty-six consecutive patients with MS were autografted in a single center using non-frozen peripheral blood stem cells (PBSCs), on an outpatient basis and conditioning with cyclophosphamide and rituximab. The protocol was registered in ClinicalTrials.gov identifier NCT02674217. One hundred and ninety-four females and 92 males were included; the median age was 47. All procedures were started on an outpatient basis and only 8 persons needed to be admitted to the hospital during the procedure. In order to obtain at least 1 × 106/kg viable CD34 cells, 1-4 aphereses were performed (median 1). The total number of viable CD34+ cells infused ranged between 1 and 19.2 × 106/kg (median 4.6). Patients recovered above 0.5 × 109/L absolute granulocytes on median day 8 (range 0-12). Two individuals needed red blood cells but none needed platelet transfusions. There were no transplant-related deaths and the 128-month overall survival of the patients is 100%. In 82 persons followed up for 3 or more months, the Expanded Disability Status Scale diminished from a mean o...Continue Reading

References

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Dec 22, 1999·Archives of Medical Research·G J Ruiz-ArgüellesA Marín-López
Apr 3, 2001·American Journal of Hematology·G J Ruiz-ArgüellesJ C Jaime-Pérez
Nov 15, 2002·International Journal of Hematology·Guillermo J Ruiz-Argüelles
Apr 8, 2009·Bone Marrow Transplantation·A López-OteroG J Ruiz-Argüelles
Apr 25, 2012·Hematology·Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles
Oct 29, 2014·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Sigbjørn Rogne
Feb 28, 2017·JAMA Neurology·Paolo A MuraroUNKNOWN Multiple Sclerosis–Autologous Hematopoietic Stem Cell Transplantation (MS-AHSCT) Long-term Outcomes Study Group

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Citations

Jul 26, 2019·Stem Cells International·Maria GavriilakiAchilles Anagnostopoulos
Aug 14, 2020·Hematology·Juan Carlos Olivares GazcaGuillermo José Ruiz Argüelles
Jun 29, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Kaja KasarełłoAgnieszka Cudnoch-Jędrzejewska
Jul 25, 2021·International Journal of Molecular Sciences·Inez WensNathalie Cools

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