A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs

Computational and Mathematical Methods in Medicine
Sanghun ChoiChing-Long Lin

Abstract

This study aims to investigate the effect of altered structures and functions in severe asthma on particle deposition by using computational fluid dynamics (CFD) models. Airway geometrical models of two healthy subjects and two severe asthmatics were reconstructed from computed tomography (CT) images. Subject-specific flow boundary conditions were obtained by image registration to account for regional functional alterations of severe asthmatics. A large eddy simulation (LES) model for transitional and turbulent flows was applied to simulate airflows, and particle transport simulations were then performed for 2.5, 5, and 10 μm particles using CFD-predicted flow fields. Compared to the healthy subjects, the severe asthmatics had a smaller air-volume change in the lower lobes and a larger air-volume change in the upper lobes. Both severe asthmatics had smaller airway circularity (Cr), but one of them had a significant reduction of hydraulic diameter (Dh). In severe asthmatics, the larger air-volume change in the upper lobes resulted in more particles in the upper lobes, especially for the small 2.5 μm particles. The structural alterations measured by Cr and Dh were associated with a higher particle deposition. Dh was found to be t...Continue Reading

References

Oct 4, 2000·Annals of Biomedical Engineering·M Howatson TawhaiP J Hunter
Feb 15, 2001·The New England Journal of Medicine·W W Busse, R F Lemanske
Jul 5, 2005·Respiratory Physiology & Neurobiology·Jose G VenegasMarcos F Vidal Melo
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Sally E WenzelUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Nov 10, 2007·Journal of Applied Physiology·Ronald L SorknessUNKNOWN National Heart, Lung, and Blood Institute Severe Asthma Research Program
Oct 9, 2009·Medical Physics·Youbing YinChing-Long Lin
Oct 6, 2010·Seminars in Nuclear Medicine·Gregory G KingSriram Mahadev
Nov 19, 2010·Radiology·Jan W De BackerWilfried De Backer
Jan 17, 2012·Annals of Biomedical Engineering·Shinjiro MiyawakiChing-Long Lin
Mar 31, 2015·Journal of Applied Physiology·Sanghun ChoiChing-Long Lin
Feb 2, 2017·The Journal of Allergy and Clinical Immunology·Sanghun ChoiUNKNOWN National Heart, Lung and Blood Institute's Severe Asthma Research Program

❮ Previous
Next ❯

Citations

May 11, 2019·Journal of Biomechanical Engineering·Bora SulAnders Wallqvist
Sep 13, 2019·Journal of Applied Physiology·Kamran PoorbahramiJessica M Oakes
Apr 9, 2021·Computer Methods and Programs in Biomedicine·Mohamed TalaatJinxiang Xi

❮ Previous
Next ❯

Software Mentioned

RMB
TriRUL
Apollo
Gmesh

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.