A feed-forward regulatory loop between androgen receptor and PlncRNA-1 promotes prostate cancer progression

Cancer Letters
Ziyu FangYinghao Sun

Abstract

We previously reported that PlncRNA-1, a long non-coding RNA that is up-regulated in prostate cancer (PCa), affects the proliferation and apoptosis of PCa cells. However, the molecular mechanisms underlying these effects remain largely unknown. In this study, we demonstrated that long non-coding RNA PlncRNA-1, whose expression is promoted by Androgen Receptor (AR), protects AR from microRNA-mediated suppression in PCa cells. PlncRNA-1 knockdown resulted in the up-regulation of a series of AR-targeting microRNAs, among which miR-34c and miR-297 were found to regulate both AR and PlncRNA-1 expression at the post-transcriptional level. Functional analysis revealed that miR-34c and miR-297 overexpression down-regulated AR expression and inhibited the expression of downstream AR targets and that PlncRNA-1 overexpression rescued these effects. The association of PlncRNA-1 with tumor progression was also evaluated in mouse xenograft models, PCa tissues (16 paired samples), and blood samples (35 biopsy-negative and 37 biopsy-positive). Together, the data generated in this study indicate that PlncRNA-1 sponges AR-targeting microRNAs to protect AR from microRNA-mediated down-regulation and that these events form a regulatory feed-forward...Continue Reading

References

Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·V SrikantanS Srivastava
Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I Scher, Charles L Sawyers
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
Feb 4, 2009·Nucleic Acids Research·Shanfa LuVincent L Chiang
Feb 24, 2011·Cancer Research·Päivi ÖstlingOlli Kallioniemi
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Zandra HagmanYvonne Ceder
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
May 7, 2013·The EMBO Journal·Ken-Ichi TakayamaSatoshi Inoue
Jun 4, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shancheng RenYinghao Sun
Jul 17, 2013·Cancer Letters·Wen ChengJiangdong Wang
Oct 23, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eva M BoltonAntoinette S Perry
Jun 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chunyu JinMichael G Rosenfeld
Jul 18, 2014·Molecular Cancer Research : MCR·Rohit MalikArul M Chinnaiyan

❮ Previous
Next ❯

Citations

Aug 25, 2016·Cell Proliferation·Yunchuan SunJianqiang Bi
Feb 10, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Baosong XingJing Wang
Jun 10, 2017·International Journal of Molecular Sciences·Ping Gao, Gong-Hong Wei
Mar 1, 2019·Endocrine-related Cancer·Rayzel FernandesLuke A Selth
Jul 17, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jie ChenNonghua Lu
May 21, 2019·International Journal of Cancer. Journal International Du Cancer·Xiaolei ShiYinghao Sun
Jan 17, 2017·Bulletin of Experimental Biology and Medicine·A I Osip'yantsB Ya Alekseev
Feb 9, 2019·Medicine·Zhenguo LuoChunsheng Wang
Aug 10, 2017·Molecular Medicine Reports·Wenyi ZhuJun Zhou
Aug 4, 2020·Asian Journal of Urology·Ieva EringyteClaire E Fletcher
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Yongyong YangQi Cao
Jun 18, 2021·Frontiers in Oncology·Margherita PiccolellaElio Messi
Jun 17, 2019·Pathology, Research and Practice·Ming Yang, Wenbin Wei
Apr 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaolong WangYing Bian
Mar 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yunxing ZhangHongxia Cui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis