A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function.

BMC Genomics
Anthony Baines

Abstract

Proteins containing FERM domains comprise a diverse group of eukaryotic proteins that bind membrane proteins and lipids. In doing so, they organise membrane microstructure, and coordinate the disposition of signalling and cell adhesion complexes. In protein 4.1R, phosphorylation adjacent to the FERM domain regulates its activity, and membrane mechanical properties. A novel sequence domain has been detected in a subset of proteins that contain FERM domains. This subset includes the true 4.1 proteins, some tyrosine phosphatases, rho-GEF proteins and type II transmembrane proteins, as well as some uncharacterised FERM proteins. This FERM-adjacent region is always closely proximate to the C-terminal of the FERM domain. This sequence is likely to be folded with elements of alpha and beta structure. The FERM-adjacent region of 4.1R contains serine residues phosphorylated by PKC and PKA; these appear conserved in about half of all other FERM-adjacent regions. Phylogenetic analyses indicate that all proteins containing a FERM-adjacent region arose from a single ancestor after FERM domains had started to proliferate in genomes of animals, plants and mycetozoa. The FERM-adjacent region defines a subset of the FERM proteins in animals. Th...Continue Reading

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Citations

Mar 31, 2011·Molecules and Cells·Boram ChoiNam Jeong Cho
Feb 15, 2013·Human Molecular Genetics·Rachel J WatkinsSue Shackleton
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Methods Mentioned

BETA
X-ray
GTPases

Software Mentioned

Chroma
PRED
Disopred
Phylip
PSSM
BLAST2
HMALIGN
PSI
JPRED
3D

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