A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines

Journal of Inorganic Biochemistry
Anne VessièresRobert-Alain Toillon

Abstract

The aim of this work was to investigate the mechanism of action of ferrocifen (Fc-OH-TAM), the ferrocenyl analog of 4-hydroxy-tamoxifen (OH-TAM), which is the active metabolite of tamoxifen, the drug most widely prescribed for treatment of hormone-dependent breast cancers. Fc-OH-TAM showed an anti-proliferative effect on the six breast cancer cell lines tested, 3 ERalpha positive (MCF-7, T-47D, ZR-75-1) and 3 ERalpha negative (MDA-MB-231, SKBR-3, Hs578-T) whatever their ER (estrogen receptor) status. However, the mechanism of action of the ferrocenyl derivative appeared to differ depending on the status of the ERalpha. Analysis of cell cycle distribution revealed that Fc-OH-TAM first recruits cells in the S phase in both ERalpha positive and ERalpha negative cells. In the presence of ERalpha, Fc-OH-TAM allowed cell cycle progression, with a subsequent blockade in G0/G1, whereas in the absence of ERalpha, cells remained in the S phase. Significant production of ROS was observed only in the presence of Fc-OH-TAM in both ERalpha positive and negative breast cancer cell lines. Within our experimental conditions, this ROS production is associated with cell cycle arrest and senescence rather than apoptosis. In the presence of ERalpha...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jul 14, 2001·Nucleic Acids Research·C M Klinge
Oct 12, 2001·Apoptosis : an International Journal on Programmed Cell Death·S Mandlekar, A N Kong
Feb 13, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hiroaki IwasaFuyuki Ishikawa
Feb 6, 2004·Breast Cancer Research and Treatment·Marc Lacroix, Guy Leclercq
Apr 29, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Ioanna LaïosGuy Leclercq
Sep 2, 2005·Breast Cancer Research and Treatment·R A ToillonG Leclercq
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·A KallioP Härkönen
Jan 13, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Anne VessièresGérard Jaouen
Feb 18, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Grzegorz Bartosz
Mar 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Robert-Alain ToillonMarc Lacroix
Jun 27, 2007·Archives of Toxicology·Katarzyna WozniakJanusz Blasiak
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U Lin, Eric P Winer
Apr 15, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Eric R ProssnitzJeffrey B Arterburn
May 8, 2008·Clinical & Experimental Metastasis·T BlickE W Thompson
Jul 22, 2008·Medicinal Research Reviews·George G ChenGary Mk Tse
Oct 11, 2008·Journal of Cellular Biochemistry·Carolyn M Klinge
Nov 8, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sherene Loi

❮ Previous
Next ❯

Citations

Jun 28, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Feng ZhaoZai-Qun Liu
Jul 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yan-Feng Li, Zai-Qun Liu
May 11, 2011·International Journal of Pharmaceutics·Mathilde RogerPhilippe Menei
May 1, 2016·Journal of Inorganic Biochemistry·Valeria ScalconMaria Pia Rigobello
Aug 27, 2014·ChemMedChem·Alane Cabral de OliveiraLetícia V Costa-Lotufo
Sep 28, 2014·Journal of Inorganic Biochemistry·Céline BruyèreRobert Kiss
Oct 22, 2015·Chemical Society Reviews·Gérard JaouenSiden Top
Jun 22, 2017·Metallomics : Integrated Biometal Science·Valeria ScalconMaria Pia Rigobello
Jun 9, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Matthieu BeauperinGérard Jaouen
Jun 16, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Chilaluck C KonkankitJustin J Wilson
Aug 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Supojjanee SansookSimon J Morley
Jan 16, 2019·Future Medicinal Chemistry·Peter V SimpsonMarco Falasca
Mar 29, 2014·Metallomics : Integrated Biometal Science·Cai-Ping TanZong-Wan Mao
Mar 4, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Sethu RamakrishnanMallayan Palaniandavar
Mar 17, 2020·Chembiochem : a European Journal of Chemical Biology·Matthew AllisonRianne M Lord
Aug 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Mathilde BouchéPhilippe C Gros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.