A Ferrous Iron Exporter Mediates Iron Resistance in Shewanella oneidensis MR-1

Applied and Environmental Microbiology
Brittany D BennettJeffrey A Gralnick

Abstract

Shewanella oneidensis strain MR-1 is a dissimilatory metal-reducing bacterium frequently found in aquatic sediments. In the absence of oxygen, S. oneidensis can respire extracellular, insoluble oxidized metals, such as iron (hydr)oxides, making it intimately involved in environmental metal and nutrient cycling. The reduction of ferric iron (Fe(3+)) results in the production of ferrous iron (Fe(2+)) ions, which remain soluble under certain conditions and are toxic to cells at higher concentrations. We have identified an inner membrane protein in S. oneidensis, encoded by the gene SO_4475 and here called FeoE, which is important for survival during anaerobic iron respiration. FeoE, a member of the cation diffusion facilitator (CDF) protein family, functions to export excess Fe(2+) from the MR-1 cytoplasm. Mutants lacking feoE exhibit an increased sensitivity to Fe(2+). The export function of FeoE is specific for Fe(2+), as an feoE mutant is equally sensitive to other metal ions known to be substrates of other CDF proteins (Cd(2+), Co(2+), Cu(2+), Mn(2+), Ni(2+), or Zn(2+)). The substrate specificity of FeoE differs from that of FieF, the Escherichia coli homolog of FeoE, which has been reported to be a Cd(2+)/Zn(2+) or Fe(2+)/Zn(...Continue Reading

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Citations

Jun 13, 2017·Metallomics : Integrated Biometal Science·Hualiang Pi, John D Helmann
Jan 31, 2018·Journal of Bacteriology·Brittany D BennettJeffrey A Gralnick
Jan 14, 2018·Applied and Environmental Microbiology·Brittany D BennettJeffrey A Gralnick
Jun 29, 2018·Metallomics : Integrated Biometal Science·Alexandrea E SestokAaron T Smith
Mar 30, 2016·The Journal of Biological Chemistry·Sarju J PatelJosé M Argüello
Oct 14, 2020·The Journal of Biological Chemistry·Justin M BradleyNick E Le Brun
Jun 30, 2019·Free Radical Biology & Medicine·B D Bennett, J A Gralnick
Jan 18, 2021·The Journal of Biological Chemistry·Justin M BradleyNick E Le Brun

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