A few good responses: which mechanical effects of IOP on the ONH to study?

Investigative Ophthalmology & Visual Science
Ian A Sigal, J L Grimm

Abstract

The biomechanical effects of IOP on the optic nerve head (ONH) are believed to play a role in glaucomatous neuropathy. There is, however, no consensus on which effects of IOP should be prioritized for investigation. Our goal was to identify a small set of variables capturing the majority of the effects of acute IOP on the ONH. We produced 4646 finite element models of the human ONH representing a wide range of tissue anatomies and mechanical properties. The effects of IOP were quantified through a set of 25 responses including stress, strain, and geometric deformation of the lamina cribrosa (LC) and peripapillary sclera. The correlations between the responses were analyzed and principal component analysis (PCA) was used to identify uncorrelated variables capturing the largest possible variance in the responses. The responses formed groups with strong correlations. The top five principal components (PCs) accounted for 72.8%, 13.0%, 7.1%, 3.1%, and 2.0% of the variance, respectively. Few PCs capture the majority of the mechanical effects of acute changes in IOP on the ONH, which previously required 25 measures. The PCs represented four key effects of IOP: lateral deformation associated with canal expansion (PC1), anterior-posteri...Continue Reading

Citations

Feb 11, 2014·Mathematical Biosciences and Engineering : MBE·Giovanna GuidoboniBrent A Siesky
Aug 14, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Charles W McMonnies
Apr 16, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Charles W McMonnies
Jun 25, 2016·Experimental Eye Research·A P VoorheesI A Sigal
Dec 21, 2013·Journal of Biomechanical Engineering·Ian C CampbellC Ross Ethier
Apr 2, 2020·Journal of the Royal Society, Interface·Stephen A SchwanerC Ross Ethier
Dec 19, 2020·The British Journal of Ophthalmology·Xiaofei WangMichael Ja Girard

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