A fibrinous and allogeneic fibroblast-enriched membrane as a biocompatible material can improve diabetic wound healing

Biomaterials Science
Seyedeh Mehrnaz KouhbananinejadAlireza Farsinejad

Abstract

The application of conventional approaches to diabetic wound regeneration has some limitations. Thus, skin substitutes could be a new therapeutic possibility. In this regard, fibrin scaffolds are promising materials due to their desirable characteristics. Since defective fibroblasts caused by diabetes can disrupt regeneration, it seems that the use of living cells can improve the healing process. Thus, based on this fact, a cellular fibrin membrane was used to evaluate the diabetic wound healing in rats. The fibrin membrane was fabricated using fresh frozen plasma on which isolated fibroblasts were cultured. The wound model was created on 36 diabetic rats that were randomly divided into three groups: control, membrane, and cellular fibrin membrane (CM). Wound photogramography and immuno-histopathological staining were performed during consecutive days after treatment. Macroscopic evaluation of the wounds indicated a noteworthy enhancement of wound closure in the CM group. In the CM group, the re-epithelialization rate on day 7, 10 (p < 0.001), and 14 (p < 0.05), the fibroblast percentage on day 3 (p < 0.01) and 7 (p < 0.05) and the collagenization in all days were significantly higher than those of other groups (p < 0.001). The...Continue Reading

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Citations

Jul 22, 2020·Molecular Biology Reports·Fereshteh Shojaei-GhahrizjaniMehdi Banitalebi-Dehkordi
Nov 28, 2020·Regenerative Medicine·Lucía Martínez-SantamaríaMaría-José Escámez
Jan 31, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Vinu VijayanManikantan Syamala Kiran

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BETA
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SPSS Statistics
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