A field method for near real-time analysis of perchloroethylene in end-exhaled breath

Journal of Occupational and Environmental Hygiene
Nathaniel D SweetGlenn Talaska

Abstract

The field method for near real-time analysis of perchloroethylene (Perc) in breath is simple, fast, and reproducible for Perc breath analysis in field settings and should prove useful in industrial hygiene practice. The method allows Perc monitoring with good specificity to the sub-part per million (ppm) level within minutes of exposure. A commercially available, portable gas chromatograph with a photoionization detector was used in these analyses. Gas chromatograph settings were optimized in the laboratory for measurement of Perc in Tedlar bags. Laboratory development of the method included evaluation of the sensitivity, specificity, precision, and speed of analysis for Perc. Replicate aliquots of Perc at concentrations ranging from 0.01 to 100 ppm were used to construct a calibration curve. The mean retention time for Perc was 238 sec. The impact of potential interference by acetone, toluene, isoprene, methanol, ethanol, acetaldehyde, carbon tetrachloride, benzene, or chloroform was evaluated by mixing Perc with each compound and performing analyses. Measurements of Perc in human breath samples collected in Tedlar bags in a workplace setting were made and compared to measurements of the same samples made by an established ana...Continue Reading

References

Aug 14, 1975·International Archives of Occupational and Environmental Health·A C Monster, G Boersma
Jun 1, 1991·Scandinavian Journal of Work, Environment & Health·S M RappaportJ Woodlee
Jun 1, 1986·Scandinavian Journal of Work, Environment & Health·H K Wilson
Jan 1, 1985·American Journal of Industrial Medicine·R L Zielhuis
Jul 1, 1974·Archives of Environmental Health·R D StewartJ E Peterson

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Citations

Sep 29, 2012·Journal of Occupational and Environmental Hygiene·Carmen EstevanEugenio Vilanova
Mar 4, 2005·Journal of Occupational and Environmental Hygiene·William A Groves, Chandran Achutan
Apr 29, 2014·International Journal of Analytical Chemistry·Chris-Elmo Ziener, Pia-Paulin Braunsdorf
Jan 7, 2015·Expert Review of Respiratory Medicine·Massimo CorradiAntonio Mutti

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