A Filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats

Scientific Reports
Hui ChenXiaoyan Pang

Abstract

Periodontitis is a highly prevalent polymicrobial disease worldwide, yet the synergistic pattern of the multiple oral pathogens involved is still poorly characterized. Here, saliva, supragingival and subgingival plaque samples from periodontitis patients and periodontally healthy volunteers were collected and profiled with 16S rRNA gene pyrosequencing. Different oral habitats harbored significantly different microbiota, and segregation of microbiota composition between periodontitis and health was observed as well. Two-step redundancy analysis identified twenty-one OTUs, including Porphyromonas gingivalis, Tannerella forsythia and Filifactor alocis, as potential pathogens that were significantly associated with periodontitis and with two periodontitis diagnostic parameters (pocket depth and attachment loss) in both saliva and supragingival plaque habitats. Interestingly, pairwise correlation analysis among the 21 OTUs revealed that Filifactor alocis was positively correlated with seven other putative pathogens (R > 0.6, P < 0.05), forming a co-occurrence group that was remarkably enriched in all three habitats of periodontitis patients. This bacterial cluster showed a higher diagnostic value for periodontitis than did any indiv...Continue Reading

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Citations

Jun 6, 2016·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chi-Ying TsaiMing-Li Liou
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Mar 16, 2021·Journal of Dental Research·E AjaA Mishra
Jul 3, 2021·Microorganisms·Sebastian BöttgerSameh Attia

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Datasets Mentioned

BETA
SRP050141

Methods Mentioned

BETA
PCR

Software Mentioned

Matlab
aRarefactWin
Sub
LEfSe
BLAST
DOTUR
CANOCO
SPSS Statistics
R

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